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Letters Clinical risk factors for pre-eclampsia determined in early pregnancy

Clinical risk factors for pre-eclampsia early pregnancy: problems with systematic review

BMJ 2016; 353 doi: (Published 24 May 2016) Cite this as: BMJ 2016;353:i2885
  1. Basky Thilagnathan, professor and director
  1. Fetal Medicine Unit, St George’s Hospital, London SW17 0QT, UK
  1. basky{at}

We read Bartsch and colleagues’ review on clinical risk factors for pre-eclampsia with interest.1 This timely topic is of great clinical interest because it reworks the established institutional guidelines for using maternal characteristics to screen for pre-eclampsia risk in pregnancy. Although we applaud their diligent and meticulous approach, we have some reservations about this study.

The authors attributed specific risk thresholds to individual maternal risk factors in an attempt to allow clinicians to identify women who may benefit from aspirin …

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