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Long term use of proton pump inhibitors may increase risk of impaired kidney function

BMJ 2016; 353 doi: (Published 15 April 2016) Cite this as: BMJ 2016;353:i2163
  1. Susan Mayor
  1. London

Long term use of proton pump inhibitors (PPIs) for heartburn, acid reflux, or gastric ulcers is associated with a higher risk of new onset chronic kidney disease, progression of existing chronic kidney disease, and end stage renal disease, a large US study has shown.1

Reports have previously linked taking a PPI to acute kidney injury and acute interstitial nephritis. But it has been unclear whether exposure to these drugs is associated with the development or progression of chronic kidney disease.

Researchers studied the US Department …

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