Intended for healthcare professionals


Markers of brain injury and other stories . . .

BMJ 2016; 353 doi: (Published 13 April 2016) Cite this as: BMJ 2016;353:i1985

Bashed brain biomarker

The traumatised brain leaks glial fibrillary acidic protein (GFAP) and ubiquitin C-terminal hydrolase L1 (UCH-L1) into the circulation. An American study of 1831 blood samples from 584 patients drawn in the week after head injury shows how these markers change over time and correlate with computed tomography findings (JAMA Neurol doi:10.1001/jamaneurol.2016.0039). But it’s not clear how this helps clinical management, and press hype about this “simple blood test” is taken apart in an article in Health News Review (

Treatment resistant schizophrenia

In a large Danish observational study, “treatment resistant” schizophrenia was defined by treatment with clozapine or hospital admission after two different drug treatments (Lancet Psychiatry doi:10.1016/S2215-0366(15)00575-1). Of 8044 patients, 1703 (21%) fulfilled these …

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