Letters
Height, body mass index, and socioeconomic status
Authors’ reply to Toth
BMJ 2016; 353 doi: https://doi.org/10.1136/bmj.i1892 (Published 05 April 2016) Cite this as: BMJ 2016;353:i1892
- Timothy M Frayling, professor of human genetics1,
- Jessica Tyrrell, research fellow1 2
- 1Genetics of Complex Traits, Institute of Biomedical and Clinical Science, University of Exeter Medical School, Royal Devon and Exeter Hospital, Exeter EX2 5DW, UK
- 2European Centre for Environment and Human Health, University of Exeter Medical School, Truro TR1 3HD, UK
- T.M.Frayling{at}exeter.ac.uk
Toth raises an important point about our mendelian randomisation study on height, body mass index, and socioeconomic status.1 2 He is troubled that the genetic polymorphisms we used explained only 12. 3% of the variation in height and 1.5% of the variation in body mass index (BMI). He suggests that this apparently small amount of variation explained by genetics makes our conclusions uncertain.
We strongly disagree. …
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