Authors’ reply to TothBMJ 2016; 353 doi: https://doi.org/10.1136/bmj.i1892 (Published 05 April 2016) Cite this as: BMJ 2016;353:i1892
- Timothy M Frayling, professor of human genetics1,
- Jessica Tyrrell, research fellow1 2
- 1Genetics of Complex Traits, Institute of Biomedical and Clinical Science, University of Exeter Medical School, Royal Devon and Exeter Hospital, Exeter EX2 5DW, UK
- 2European Centre for Environment and Human Health, University of Exeter Medical School, Truro TR1 3HD, UK
Toth raises an important point about our mendelian randomisation study on height, body mass index, and socioeconomic status.1 2 He is troubled that the genetic polymorphisms we used explained only 12. 3% of the variation in height and 1.5% of the variation in body mass index (BMI). He suggests that this apparently small amount of variation explained by genetics makes our conclusions uncertain.
We strongly disagree. …