Re: Is the timing of recommended childhood vaccines evidence based?
Jefferson and Demicheli's summation of "...comments and conflicts" is helpful, but at the risk of tiresome repetition I call attention to a population-based cohort study which found that children receiving DTaP-IPV-Hib after MMR at 12-15 months had 62% more hospitalizations for infections during the second year of life compared with those who received DTaP-IPV-Hib followed by MMR. (IRR , 1.62--CI, 1.28 to 2.05). This was a non-randomized observational study in Denmark, but provides some evidence that the timing of vaccines could be very important. (Sorup, Aaby, et al. JAMA 311:826, 2014).
Competing interests: No competing interests