Intended for healthcare professionals

Rapid response to:

Head To Head

Is the timing of recommended childhood vaccines evidence based?

BMJ 2016; 352 doi: https://doi.org/10.1136/bmj.i867 (Published 23 February 2016) Cite this as: BMJ 2016;352:i867

Rapid Response:

Re: Is the timing of recommended childhood vaccines evidence based?

Jefferson and Demicheli's summation of "...comments and conflicts" is helpful, but at the risk of tiresome repetition I call attention to a population-based cohort study which found that children receiving DTaP-IPV-Hib after MMR at 12-15 months had 62% more hospitalizations for infections during the second year of life compared with those who received DTaP-IPV-Hib followed by MMR. (IRR , 1.62--CI, 1.28 to 2.05). This was a non-randomized observational study in Denmark, but provides some evidence that the timing of vaccines could be very important. (Sorup, Aaby, et al. JAMA 311:826, 2014).

Competing interests: No competing interests

22 March 2016
Allan S. Cunningham
Retired pediatrician
Cooperstown NY 13326