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Letters Maternal vaccination against H1N1 influenza and offspring mortality

Authors’ reply to Makiyama and colleagues

BMJ 2016; 352 doi: (Published 16 February 2016) Cite this as: BMJ 2016;352:i776
  1. Jonas F Ludvigsson, professor of clinical epidemiology and paediatrician1,
  2. Peter Ström, statistician1,
  3. Cecilia Lundholm, statistician1,
  4. Sven Cnattingius, professor of reproductive epidemiology2,
  5. Anders Ekbom, professor of epidemiology2,
  6. Åke Örtqvist, associate professor3,
  7. Nils Feltelius, associate professor4,
  8. Fredrik Granath, statistician2,
  9. Olof Stephansson, associate professor2
  1. 1Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Sweden
  2. 2Clinical Epidemiology Unit, Department of Medicine Solna, Karolinska Institutet, Sweden
  3. 3Unit of Infectious Diseases, Department of Medicine, Karolinska Institutet, Sweden
  4. 4Medical Product Agency, Uppsala, Sweden
  1. jonasludvigsson{at}

In response to Junya and colleagues’ concerns we recalculated the risk of offspring mortality with offspring to women who were vaccinated at 0-1 months before conception being classified as exposed.1 2 This did not change the risk estimates more than marginally (for example, the hazard ratio for fetal death went from 0.83 to 0.86 in the population based …

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