Hemkens et al. still do not acknowledge the bias of the inversion method that they used. This bias has nothing to do with regression to the mean. As a complement to the previously presented mathematical proof, we have posted a summary of some simulation results that may be easier to digest, indicating the magnitude and direction of the bias. It is available at http://www.drugepi.org/faculty-staff-trainees/faculty/jessica-franklin/.
Competing interests:
No competing interests
28 November 2017
Jessica M. Franklin
Assistant Professor of Medicine
Sara Dejene, Krista F. Huybrechts, Shirley V. Wang, Martin Kulldorff, and Kenneth J. Rothman
Brigham and Women's Hospital and Harvard Medical School
Rapid Response:
Re: The authors respond
Hemkens et al. still do not acknowledge the bias of the inversion method that they used. This bias has nothing to do with regression to the mean. As a complement to the previously presented mathematical proof, we have posted a summary of some simulation results that may be easier to digest, indicating the magnitude and direction of the bias. It is available at http://www.drugepi.org/faculty-staff-trainees/faculty/jessica-franklin/.
Competing interests: No competing interests