Intended for healthcare professionals


Computerised cognitive behaviour therapy (cCBT) as treatment for depression in primary care (REEACT trial): large scale pragmatic randomised controlled trial

BMJ 2016; 352 doi: (Published 12 January 2016) Cite this as: BMJ 2016;352:i195

The original trial registration for this Research paper (BMJ 2015;351:h5627, doi:10.1136/bmj.h5627), the REEACT trial (, included depression as a primary outcome, measured in two ways: “Depression severity and symptomatology as measured by a validated self-report measure (the Patient Health Questionnaire [PHQ-9]) and the International Classification of Diseases (ICD-10) depression score at four months.” The original protocol defined the primary outcome measure as “depression severity and symptomatology as measured by the PHQ-9 and a self-report computer-administered diagnostic interview (CIS-R) at four months.” Before the start of the trial, the primary outcome measure was modified to consist of only the PHQ-9 at four months. We did not collect ICD diagnosed depression using a standardised interview schedule. The public document detailing all revisions can be accessed in the full report at One of our outcomes was a measure of quality adjusted life years, which is published in the full economic evaluation at


Cite this as: BMJ 2016;352:i195

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