Re: Decompensated alcohol related liver disease: acute management
In regards to your article 'Decompensated alcohol related liver disease: acute management' ,the Lille model is mentioned as a method of calculating steroid responsiveness. After STOPAH (The clinical effectiveness and cost-effectiveness of STeroids Or Pentoxifylline for Alcoholic Hepatitis (STOPAH) the evidence suggests prednisolone's benefit beyond 28 days is non sustained. The Lille Model suggests a significant benefit in complete or partial responders to steroids, based on a model using 6 month mortality data. With the results from STOPAH, is the Lille Model still a valid way of assessing steroid responsiveness and should further work be look
ed into constructing other models to assess steroid responsiveness
Competing interests:
No competing interests
13 February 2016
Vinoth Nadesalingam
Gastroenterology Registrar
Benjamin Cooper
Royal London Hospital, Whitechapel, London, E1 1BB
Rapid Response:
Re: Decompensated alcohol related liver disease: acute management
In regards to your article 'Decompensated alcohol related liver disease: acute management' ,the Lille model is mentioned as a method of calculating steroid responsiveness. After STOPAH (The clinical effectiveness and cost-effectiveness of STeroids Or Pentoxifylline for Alcoholic Hepatitis (STOPAH) the evidence suggests prednisolone's benefit beyond 28 days is non sustained. The Lille Model suggests a significant benefit in complete or partial responders to steroids, based on a model using 6 month mortality data. With the results from STOPAH, is the Lille Model still a valid way of assessing steroid responsiveness and should further work be look
ed into constructing other models to assess steroid responsiveness
Competing interests: No competing interests