Intended for healthcare professionals

Rapid response to:

Clinical Review

Decompensated alcohol related liver disease: acute management

BMJ 2016; 352 doi: (Published 26 January 2016) Cite this as: BMJ 2016;352:i124

Rapid Response:

Re: Decompensated alcohol related liver disease: acute management

In regards to your article 'Decompensated alcohol related liver disease: acute management' ,the Lille model is mentioned as a method of calculating steroid responsiveness. After STOPAH (The clinical effectiveness and cost-effectiveness of STeroids Or Pentoxifylline for Alcoholic Hepatitis (STOPAH) the evidence suggests prednisolone's benefit beyond 28 days is non sustained. The Lille Model suggests a significant benefit in complete or partial responders to steroids, based on a model using 6 month mortality data. With the results from STOPAH, is the Lille Model still a valid way of assessing steroid responsiveness and should further work be look
ed into constructing other models to assess steroid responsiveness

Competing interests: No competing interests

13 February 2016
Vinoth Nadesalingam
Gastroenterology Registrar
Benjamin Cooper
Royal London Hospital, Whitechapel, London, E1 1BB