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Ibuprofen versus fosfomycin for uncomplicated urinary tract infection in women: randomised controlled trial

BMJ 2015; 351 doi: https://doi.org/10.1136/bmj.h6544 (Published 23 December 2015) Cite this as: BMJ 2015;351:h6544

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Re: Ibuprofen versus fosfomycin for uncomplicated urinary tract infection in women: randomised controlled trial

Author´s reply: Thank you for this comment. We agree that the potential antimicrobial properties of ibuprofen are an important factor which is, however, still under discussion. Obad et al. showed that for E. coli, the main causative agent for urinary tract infection (UTI), no inhibition zones were obtained in a disk diffusion assay with ibuprofen. Thus, for UTI the antimicrobial effect of ibuprofen remains unclear. Further research is needed, as planned in a Scandinavian UTI trial by Vik et al.

Vik I, Bollestad M, Grude Net al. Ibuprofen versus mecillinam for uncomplicated cystitis--a randomized controlled trial study protocol. BMC Infect Dis 2014;14: 693
Obad J, Šušković J, Kos B. Antimicrobial activity of ibuprofen: new perspectives on an "Old" non-antibiotic drug. Eur J Pharm Sci. 2015 Apr 25;71:93-8

Competing interests: No competing interests

22 February 2016
Jutta Bleidorn
senior research fellow, family physician
Ildikó Gágyor, Eva Hummers-Pradier
Institute for General Practice, Medical School Hannover
Carl-Neuberg-Str.1, 30625 Hannover, Germany