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PrEP on demand cuts HIV transmission in high risk men, study finds

BMJ 2015; 351 doi: (Published 01 December 2015) Cite this as: BMJ 2015;351:h6468
  1. Michael McCarthy
  1. 1Seattle

Pre-exposure prophylaxis (PrEP) taken by men when they have sex with other men reduced the risk of transmission of HIV-1 by 86%, a new randomized, placebo controlled trial published in the New England Journal of Medicine has found.1

Previous trials have shown that PrEP taken daily can reduce HIV-1 transmission among men who have sex with men, heterosexual men and women, intravenous drug users, and serodiscordant couples. However, adherence remains a challenge. The hypothesis of the new study, conducted in France and Canada, was that PrEP taken on demand instead of part of a once a day regimen would achieve greater adherence and thus greater efficacy.

In the trial, called the Intervention Préventive de l’Expostion aux Risque avec et pour les Gays (IPERGAY) trial, 400 men who had tested negative for HIV and who engaged in unprotected anal sex with men were randomized to take either …

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