Intended for healthcare professionals


Many cancer drugs recently approved in US do not improve overall survival, study finds

BMJ 2015; 351 doi: (Published 23 October 2015) Cite this as: BMJ 2015;351:h5634
  1. Michael McCarthy
  1. 1Seattle

In recent years most cancer drug approvals by the US Food and Drug Administration have been made on the basis of a surrogate endpoint, such as tumour response rate or progression-free survival. When such approvals are made the agency typically advises or requires that post-approval studies be conducted to clarify the drug’s effect on overall survival.

However, a new US study has found that, in most cases, cancer drugs that have recently secured FDA …

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