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Fewer live births occur with letrozole than standard therapy for unexplained infertility, study shows

BMJ 2015; 351 doi: (Published 25 September 2015) Cite this as: BMJ 2015;351:h5070
  1. Susan Mayor
  1. 1London

Ovarian stimulation with letrozole results in fewer multiple pregnancies but a lower rate of live births than standard therapy with gonadotrophin or clomiphene, a study reported in the New England Journal of Medicine has shown.1

Researchers enrolled 900 couples with unexplained infertility from 12 US centres to the study, which was funded by the National Institutes of Health and other research institutions. The women, who were aged 18 to 40 and had at …

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