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Androgen deprivation therapy should be used with caution in some prostate cancer cases, study warns

BMJ 2015; 351 doi: (Published 22 September 2015) Cite this as: BMJ 2015;351:h5043
  1. Jacqui Wise
  1. 1London

Combining androgen deprivation and radiotherapy is known to improve outcomes in aggressive prostate cancer, but research published in JAMA shows that it should be used with caution in men with coexisting illness.1

Six months of androgen deprivation therapy and radiation therapy is the standard treatment for unfavourable risk prostate cancer. But a post-randomisation analysis found that men with moderate or severe comorbidity showed no survival benefit from combined therapy. …

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