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US oncologists update guidance on DNA sequencing in clinical practice

BMJ 2015; 351 doi: (Published 09 September 2015) Cite this as: BMJ 2015;351:h4805
  1. Michael McCarthy
  1. 1Seattle

Oncologists must exercise care as they incorporate new DNA sequencing technologies into clinical practice to maximize their benefits and minimize the potential harms, the American Society of Clinical Oncology has said in an updated policy statement on genetic and genomic testing for cancer susceptibility.1

Technologies such as massive parallel sequencing now make it possible for clinicians to sequence ever larger panels of genes and even whole genomes relatively cheaply. As a result, many oncologists are using DNA sequencing in a process called somatic mutation profiling to identify acquired sequence variations …

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