In a recent multicenter, double-blind, placebo-controlled, clinical trial, earlier administration of levodopa in combination with carbidopa did not have a disease-modifying effect or any alteration of dyskinesia rates.
Reference https://www.nejm.org/doi/full/10.1056/NEJMoa1809983
Rapid Response:
Re: Initial drug treatment in Parkinson’s disease
In a recent multicenter, double-blind, placebo-controlled, clinical trial, earlier administration of levodopa in combination with carbidopa did not have a disease-modifying effect or any alteration of dyskinesia rates.
Reference
https://www.nejm.org/doi/full/10.1056/NEJMoa1809983
Competing interests: No competing interests