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Restoring Study 329: efficacy and harms of paroxetine and imipramine in treatment of major depression in adolescence

BMJ 2015; 351 doi: https://doi.org/10.1136/bmj.h4320 (Published 16 September 2015) Cite this as: BMJ 2015;351:h4320

Re: Restoring Study 329: efficacy and harms of paroxetine and imipramine in treatment of major depression in adolescence

Study 329 is a notorious study, with its perverted results well known to any psychiatrist paying attention. It is still well worth the detailed look at how the reported results came to be, and congratulations and thanks to the authors for doing so. RIAT is a great idea and showing specific examples like the 329 study illustrates how important trial transparency is. As Drs. Healy and Nardo know, psychiatric trials are rich with similar insults to science and patient care, in my opinion.

Competing interests: No competing interests

17 September 2015
Susan Molchan
psychiatrist
Bethesda, MD