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Risk of intracranial haemorrhage in antidepressant users with concurrent use of non-steroidal anti-inflammatory drugs: nationwide propensity score matched study

BMJ 2015; 351 doi: https://doi.org/10.1136/bmj.h3517 (Published 14 July 2015) Cite this as: BMJ 2015;351:h3517

Re: Risk of intracranial haemorrhage in antidepressant users with concurrent use of non-steroidal anti-inflammatory drugs: nationwide propensity score matched study

An extensive systematic review and meta-analysis of previous research studies from 1960 to 2017, totalling 4,844,090 patient-years of follow-up, found that selective serotonin reuptake inhibitors (SSRIs) increased haemorrhagic stroke. [1]
Even without concurrent use of non-steroidal anti-inflammatory drugs, administering second generation antidepressants could increase the risk of intracranial haemorrhage.
Reference
[1] https://journals.sagepub.com/doi/10.1177/2396987319827211

Competing interests: No competing interests

28 January 2019
Stavros Saripanidis
Consultant in Obstetrics and Gynaecology
Thessaloniki, Greece