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Letters Wastage in clinical trials

Some clinical trials are driven by fashion, not science

BMJ 2015; 350 doi: (Published 20 January 2015) Cite this as: BMJ 2015;350:h288
  1. Kirti Kain, senior clinical lecturer1
  1. 1Division of Cardiovascular & Diabetes Research, Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds LS2 9JT, UK
  1. k.kain{at}

Ioannidis describes the waste in clinical trials.1 Some trials—such as those on vitamin D supplementation—are driven by fashion rather than scientific merit. Despite negative results with various preparations, doses, and frequencies, trials continue to be conducted with different regimens. …

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