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Impact of smoking and smoking cessation on cardiovascular events and mortality among older adults: meta-analysis of individual participant data from prospective cohort studies of the CHANCES consortium

BMJ 2015; 350 doi: https://doi.org/10.1136/bmj.h1551 (Published 20 April 2015) Cite this as: BMJ 2015;350:h1551

Rapid Response:

Risk factors of cardiovascular events and mortality even at older age: smoking and else?

Results from a meta-analysis from prospective cohort studies of the CHANCES consortium among participants aged 60 and older revealed that smoking is a strong independent risk factor of cardiovascular (CVD) events and mortality even at older age; the estimation of risk advancement was more than five years (Mons et al., 2015).

A cohort study conducted by Cea Soriano and colleagues on the association between cardiovascular events and renal function among patients with type 2 diabetes showed that low renal function was associated with an increased risk of death, myocardial infarction (MI; HR: 2.33; 95% CI: 1.89 – 2.87), and ischemic stroke or transient ischemic attack (IS/TIA; HR: 1.77; 95% CI: 1.43 – 2.18). Cea Soriano and colleagues also reported that aging, duration of disease, poor control, and hyperlipidemia were predictors of cardiovascular events (Cea Soriano, Johansson, Stefansson, & Rodríguez, 2015). In addition, a prospective study about asthma and cardiovascular events ound that persistent asthmatics had a greater risk of CVD events than non-asthmatics (HR: 1.6; 95% CI: 1.01–2.5), even after adjustment for age, sex, race, CVD risk factors, and antihypertensive and lipid medication use (Tattersall et al., 2015).

Apart from smoking, there were many other risk factors for cardiovascular diseases among older people such as metabolism, hormones, aging, duration of diseases. Cardiovascular events and mortality even are also caused by complications of other diseases including diabetes, kidney diseases, and asthma.

References
Cea Soriano, L., Johansson, S., Stefansson, B., & Rodríguez, L. A. G. (2015). Cardiovascular events and all-cause mortality in a cohort of 57,946 patients with type 2 diabetes: associations with renal function and cardiovascular risk factors. Cardiovascular Diabetology, 14, 38. doi: 10.1186/s12933-015-0204-5

Mons, U., Müezzinler, A., Gellert, C., Schöttker, B., Abnet, C. C., Bobak, M., . . . Kee, F. (2015). Impact of smoking and smoking cessation on cardiovascular events and mortality among older adults: meta-analysis of individual participant data from prospective cohort studies of the CHANCES consortium. BMJ, 350, h1551.

Tattersall, M. C., Guo, M., Korcarz, C. E., Gepner, A. D., Kaufman, J. D., Liu, K. J., . . . Stein, J. H. (2015). Asthma Predicts Cardiovascular Disease Events: The Multi-Ethnic Study of Atherosclerosis. Arteriosclerosis, Thrombosis, and Vascular Biology. doi: 10.1161/atvbaha.115.305452

Competing interests: No competing interests

29 April 2015
Van Tuyen Duong
Scientific Researcher
Taipei Medical University
No 250, Wuxing Street, Taipei City, Taiwan, 110