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Folic acid significantly reduces risk of first stroke, large Chinese study finds

BMJ 2015; 350 doi: (Published 16 March 2015) Cite this as: BMJ 2015;350:h1461
  1. Jacqui Wise
  1. 1London

The use of folic acid for the primary prevention of stroke, particularly among populations with low folate levels, is supported by a large randomised controlled trial reported in JAMA.

The China Stroke Primary Prevention Trial included 20 702 adults with high blood pressure but without a history of stroke or heart attack.1 They were randomly assigned to receive daily treatment with 10 mg of the angiotensin converting enzyme (ACE) inhibitor enalapril and 0.8 mg folic acid or to enalapril alone.

The trial was terminated early, after 4.5 years, because of the …

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