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HRT increases risk of blood clots and stroke, finds new analysis

BMJ 2015; 350 doi: (Published 10 March 2015) Cite this as: BMJ 2015;350:h1336
  1. Nigel Hawkes
  1. 1London

Hormone replacement therapy (HRT) offers women no protection against having or dying from a myocardial infarction while increasing the risk of blood clots and stroke, a new analysis published by the Cochrane Collaboration has shown.1

But, complicating the message, a subgroup analysis of women who were given HRT below the age of 60 or within 10 years of the menopause did show a reduction in the risk of myocardial infarction and death from any cause while also showing an increased risk of blood clots and possibly stroke.

Many of the women in the 19 randomised control trials whose results were included were prescribed HRT quite late in life, at a time when the treatment’s proponents saw it as “an elixir of life” and …

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