Statins associated with 46% rise in type 2 diabetes risk, study showsBMJ 2015; 350 doi: https://doi.org/10.1136/bmj.h1222 (Published 05 March 2015) Cite this as: BMJ 2015;350:h1222
- Susan Mayor
Taking a statin is associated with a 46% increase in the risk of type 2 diabetes, a large follow-up study of men in Finland has found. The paper suggested that the effect was due to decreased insulin sensitivity and secretion. However, experts commenting on the findings have pointed out various flaws in the study and its presentation.
The study followed up 8749 men aged 45 to 73 years for an average of 5.9 years. They were randomly selected from the population of Kuopio, eastern Finland, and none had diabetes at baseline. The results, reported in Diabetologia, showed that men taking statins (n=2142) had a 46% increased risk of developing type 2 diabetes (adjusted hazard ratio 1.46 (95% confidence interval 1.22 to 1.74)) over the follow-up period.1
Type 2 diabetes was diagnosed in 625 men on the basis of measurement of fasting plasma glucose, …