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Letters Glucocorticoid replacement

Mimicking the circadian rhythm in glucocorticoid replacement

BMJ 2014; 349 doi: (Published 10 September 2014) Cite this as: BMJ 2014;349:g5518
  1. Peter C Hindmarsh, professor of paediatric endocrinology1
  1. 1Institute of Child Health, University College London, London WC1N 1EH, UK
  1. p.hindmarsh{at}

To reduce mortality and morbidity in patients with adrenal disorders, it is essential to understand glucocorticoid replacement. I agree with Amin and colleagues that we should mimic the circadian rhythm, but once daily treatment with any of the drugs suggested would not do this.1 …

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