Intended for healthcare professionals

Letters Glucocorticoid replacement

Insufficient evidence to favour prednisolone over hydrocortisone in glucocorticoid replacement

BMJ 2014; 349 doi: (Published 10 September 2014) Cite this as: BMJ 2014;349:g5510
  1. Simon H S Pearce, professor of endocrinology1
  1. 1University of Newcastle upon Tyne, Newcastle upon Tyne, UK
  1. Simon.Pearce{at}

Endocrine therapeutics is largely based on the principle that restoring the physiological pattern of hormonal secretion will control symptoms and have optimal long term health outcomes. People with adrenal insufficiency have increased morbidity and mortality from vascular disease and an increased risk of fracture.1 2 …

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