The difficulty in evaluating all findings in study on use of macrolides in mother and child and risk of infantile hypertrophic pyloric stenosisBMJ 2014; 349 doi: https://doi.org/10.1136/bmj.g5201 (Published 19 August 2014) Cite this as: BMJ 2014;349:g5201
- Frank de Vries, pharmacoepidemiologist1
- 1Utrecht Institute for Pharmaceutical Sciences, Universiteitsweg 99, Utrecht, the Netherlands
Lund and colleagues report a 30-fold risk of infantile hypertrophic pyloric stenosis with the use of macrolide antibiotics during the first 0-13 days of a child’s life.1 This is either a very strong association or too good to be true.
The authors used the Danish national databases, which linked the dispensing of drugs from community …