Research News

Severe vaccine complications are rare, review finds

BMJ 2014; 349 doi: (Published 03 July 2014) Cite this as: BMJ 2014;349:g4411
  1. Michael McCarthy
  1. 1Seattle, USA

Although some childhood vaccines are associated with severe adverse events, these complications are “extremely” rare, according to a new systematic review.1

The review, which updates and adds to the 2011 Institute of Medicine (IOM) report entitled Adverse Effects of Vaccines: Evidence and Causality, was commissioned by the US Agency for Healthcare Research and Quality to identify gaps in evidence on the safety of vaccines.2

The review focused on vaccines recommended for routine use in the US for children aged 6 years and younger: DTaP (diphtheria, tetanus, and acellular pertussis); hepatitis A; hepatitis B, haemophilus influenza type b (Hib); influenza (live attenuated and inactivated); …

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