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Smokers with gene defect have higher risk of developing lung cancer

BMJ 2014; 348 doi: (Published 02 June 2014) Cite this as: BMJ 2014;348:g3621
  1. Zosia Kmietowicz
  1. 1The BMJ

Scientists have found a previously unknown link between lung cancer and a defect in the BRCA2 gene. Smokers with the defect had a 25% chance of developing lung cancer compared with 13% in those without the genetic variant, said a report in Nature Genetics.1

The researchers, led by a team at the Institute of Cancer Research in London, compared the DNA of 11 348 Europeans with lung cancer and 15 861 without the disease and looked for differences at specific points in their DNA. They …

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