Intended for healthcare professionals


Adverse effects of statins

BMJ 2014; 348 doi: (Published 15 May 2014) Cite this as: BMJ 2014;348:g3306

Re: Adverse effects of statins

How can there be any doubt about the frequent adverse side effects of taking statins when so much money has been spent on epidemiological research and worldwide promotion of extensive use?[1]

It is extraordinary - considering that these drugs block the endogenous production of co-enzyme Q10, which is the most important acceptor and donor of electrons in the Krebs citric acid cycle (oxidative phosphorylation). Biochemist Dr John McLaren-Howard’s ATP profile test measures the rate of oxidative phosphorylation which controls the rate of ADP (adenosine diphosphate) to ATP (adenosine triphosphate) conversion.[2-4] His clinical co-author, Dr Sarah Myhill, writes that statins invariably worsen fatigue syndromes and probably also accelerate ageing.[5]

1 Godlee F. Adverse effects of statins. BMJ 2014;348:g3306

2 Myhill S, Booth NE, McLaren-Howard J. Chronic fatigue syndrome and mitochondrial dysfunction. Int J Clin Exp Med. 2009;2:1-16.

3 Booth NE, Myhill S, McLaren-Howard J. Mitochondrial dysfunction and the pathophysiology of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). Int J Clin Exp Med. 2012;5(3):208-20.

4 Myhill S, Booth NE, McLaren-Howard J. Targeting mitochondrial dysfunction in the treatment of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) - a clinical audit. Int J Clin Exp Med. 2013;6:1-15.

5. Myhill S. In "Chronic Fatigue Syndrome It’s mitochondria, not hypochondria.” 2014 Hammersmith Health Books, London PP 44-72.

Competing interests: No competing interests

16 May 2014
Ellen CG Grant
Physician and medical gynaecologist
Kingston-upon-Thames, KT2 7JU, UK