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Research

Helicobacter pylori eradication therapy to prevent gastric cancer in healthy asymptomatic infected individuals: systematic review and meta-analysis of randomised controlled trials

BMJ 2014; 348 doi: https://doi.org/10.1136/bmj.g3174 (Published 20 May 2014) Cite this as: BMJ 2014;348:g3174

Why use expensive and potentially harmful antibiotics to eradicate Helicobacter pylori, when natural oils are equally effective?

Dear Editors,
Essential oil of Origanum vulgaris(oregano), containing high quantities of carvacrol, apart from exhibiting broad spectrum bactericidal activity, even against antibiotic-resistant strains[1], broad spectrum fungicidal activity, without any side effects, even against fluconazole resistant strains[2], has also antinociceptive[6] and potent anti-inflammatory activity[3][4][5].
Carvacrol is highly bactericidal against H. pylori P1 and against other Helicobacter strains tested. [7][8]
No bacterial resistance has been observed.
References
[1] http://www.bmj.com/content/317/7159/609/rr/634773
[2] http://www.bmj.com/content/337/bmj.39357.558183.94/rr/630538
[3] http://www.ncbi.nlm.nih.gov/pubmed/22363615
[4] http://www.ncbi.nlm.nih.gov/pubmed/21382660
[5] http://www.ncbi.nlm.nih.gov/pubmed/22892022
[6] http://www.ncbi.nlm.nih.gov/pubmed/23146035
[7] http://www.ncbi.nlm.nih.gov/pubmed/14506036
[8] http://www.ncbi.nlm.nih.gov/pubmed/19769000

Competing interests: No competing interests

15 July 2014
Stavros Saripanidis
Consultant in Obstetrics and Gynaecology
Thessaloniki, Greece