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Letters Statin side effects study

Meta-analysis of side effects of statins shows need for trial transparency

BMJ 2014; 348 doi: (Published 29 April 2014) Cite this as: BMJ 2014;348:g2940
  1. Ben Goldacre, Wellcome research fellow in epidemiology1
  1. 1London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK
  1. ben.goldacre{at}

As Wise reported,1 our meta-analysis looked at side effects in randomised trials of statins and found that many, such as muscle aches, were reported to an equal degree by participants taking a placebo. Those side effects may therefore be partly non-pharmacological, and due to negative expectations, or the “nocebo” effect, as has been …

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