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Letters Prostatectomy v radiotherapy

Authors’ reply to Roach

BMJ 2014; 348 doi: (Published 25 March 2014) Cite this as: BMJ 2014;348:g2271
  1. Prasanna Sooriakumaran, senior clinical researcher1,
  2. Tommy Nyberg, statistician2,
  3. Olof Akre, associate professor3,
  4. Gunnar Steineck, professor2,
  5. Peter Wiklund, professor4
  1. 1Surgical Intervention Trials Unit, Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK
  2. 2Clinical Cancer Epidemiology, Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden
  3. 3Clinical Epidemiology Unit, Department of Medicine (Solna), Karolinska Institutet, Stockholm, Sweden
  4. 4Department of Urology, Karolinska University Hospital, Stockholm, Sweden
  1. peter.wiklund{at}

We have tried to fool none of the people none of the time.1 2 However, we acknowledge the limitations of observational data, although they can have higher statistical precision and be more generalisable than data from randomised trials.3 4 The question is whether the systematic errors in our study misled us to believe mortality is higher …

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