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Vitamin D and multiple health outcomes: umbrella review of systematic reviews and meta-analyses of observational studies and randomised trials

BMJ 2014; 348 doi: https://doi.org/10.1136/bmj.g2035 (Published 01 April 2014) Cite this as: BMJ 2014;348:g2035

Re: Vitamin D and multiple health outcomes: umbrella review of systematic reviews and meta-analyses of observational studies and randomised trials

It is asserted that low levels of 25(OH)D accurately reflect vitamin D status; (i.e., vitamin D storage and VDR-mediated control of calcium metabolism and innate immunity). However, measurement of both 1,25(OH)2D and 25(OH)D is essential to accurately assess vitamin D status and to recognize dysregulated vitamin D metabolism. Blaney et al. found that serum 25(OH)D alone is not a sensitive measure of the autoimmune disease state. Measuring both metabolites often demonstrates a positive correlation of elevated 1,25(OH)2D and low 25(OH)D to inflammatory diseases.

1. Thurnham DI. Plasma 25-Hydroxy-Cholecalciferol (Vitamin D) is Depressed by Inflammation: Implications and Parallels with Other Micronutrients. Sight Lif. 2011;25((2)).
2. Blaney GP, Albert PJ, Proal AD. Vitamin D metabolites as clinical markers in autoimmune and chronic disease. Ann N Y Acad Sci. Sep 209;1173:384-90.

Competing interests: No competing interests

21 April 2014
Meg Mangin
Registered Nurse
Chronic Illness Recovery
1620 Wilson Ave Menomonie, WI 54751