Genetic tests could detect high risk of aggressive prostate cancerBMJ 2014; 348 doi: https://doi.org/10.1136/bmj.g1700 (Published 21 February 2014) Cite this as: BMJ 2014;348:g1700
- Nigel Hawkes
Better screening tests for prostate cancer may be possible, owing to the discovery of 14 genes that are linked to more aggressive forms of the disease.
A team at the Institute of Cancer Research in London found 14 “loss of function” mutations in eight DNA repair genes in men who had a family history of prostate cancer. Men who carried these genes were 13 times as likely (95% confidence interval 2.56 to 83.95) to have an advanced form of the disease. The team said that this could improve screening by increasing the ability to distinguish between cases that …