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Genetic tests could detect high risk of aggressive prostate cancer

BMJ 2014; 348 doi: (Published 21 February 2014) Cite this as: BMJ 2014;348:g1700
  1. Nigel Hawkes
  1. 1London

Better screening tests for prostate cancer may be possible, owing to the discovery of 14 genes that are linked to more aggressive forms of the disease.

A team at the Institute of Cancer Research in London found 14 “loss of function” mutations in eight DNA repair genes in men who had a family history of prostate cancer. Men who carried these genes were 13 times as likely (95% confidence interval 2.56 to 83.95) to have an advanced form of the disease. The team said that this could improve screening by increasing the ability to distinguish between cases that …

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