Intended for healthcare professionals

Letters Sodium in drug formulations

Too early to attach blanket health warnings to all drugs containing sodium, irrespective of conjugate anion

BMJ 2014; 348 doi: (Published 12 February 2014) Cite this as: BMJ 2014;348:g1404
  1. Ossie Ferdinand Uzoigwe, medical writer1
  1. 1Sheffield, UK
  1. ofuzoigwe{at}

George and colleagues postulate that increased oral sodium load raises blood pressure, thus precipitating the adverse cardiovascular outcomes observed.1 This explanation is intuitive, cogent, and attractive but more complex processes may be at work. Not all sodium salts have a hypertensive effect. It has been well established since the 1980s that the pressor effect associated with sodium salts is restricted to sodium chloride and other halides. It does not occur with non-halide sodium salts.2 3 4 5 …

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