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Letters Antiphospholipid antibody testing

Irrational testing for antiphospholipid antibodies

BMJ 2013; 347 doi: (Published 23 December 2013) Cite this as: BMJ 2013;347:f7491
  1. Catherine Nelson-Piercy, professor of obstetric medicine1,
  2. Beverely J Hunt, professor of thrombosis and haemostasis, King’s College London1,
  3. Munther Khamashta, professor of rheumatology, Women’s Health Academic Centre, King’s College London1,
  4. Lucy C Chappell, clinical senior lecturer in maternal fetal medicine, Women’s Health Academic Centre, King’s College London1
  1. 1Guy’s and St Thomas’ NHS Foundation Trust, St Thomas’ Hospital, London SE1 7EH, UK
  1. catherine.nelson-piercy{at}

We read Binder and Ellis’s article with interest,1 but the incongruity of recommending irrational testing in a “Rational Testing” article did not escape us.

The authors advise testing women with a history of two miscarriages for antiphospholipid antibodies, despite clinical classification criteria for antiphospholipid syndrome stipulating three or more …

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