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Letters Chronic fatigue treatment trial

PACE trial authors’ reply to letter by Kindlon

BMJ 2013; 347 doi: (Published 15 October 2013) Cite this as: BMJ 2013;347:f5963
  1. P D White, professor of psychological medicine1,
  2. T Chalder, professor of cognitive behavioural psychotherapy2,
  3. M Sharpe, professor of psychological medicine3,
  4. T Johnson, senior statistician4,
  5. K Goldsmith, clinical trials unit statistician5
  1. 1Wolfson Institute of Preventive Medicine, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK
  2. 2Academic Department of Psychological Medicine, King’s College London, London, UK
  3. 3Department of Psychiatry, University of Oxford, Oxford, UK
  4. 4Medical Research Council Clinical Trials Unit at UCL, London, UK
  5. 5Biostatistics Department, Institute of Psychiatry, King’s College London, London, UK
  1. p.d.white{at}

Kindlon states that access to the committee minutes of the PACE (Pacing, Graded Activity, and Cognitive Behaviour Therapy—a Randomised Evaluation) trial is needed “to find out why outcome measures were changed.”1 We disagree.

Firstly, the primary outcome measures were the same as those described in the protocol—fatigue and physical disability.2

Secondly, details and explanations of …

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