Intended for healthcare professionals

Letters Restoring the clinical trial evidence base

Hidden or misreported trial results cause widespread patient harm

BMJ 2013; 347 doi: (Published 10 July 2013) Cite this as: BMJ 2013;347:f4393
  1. Donald W Light, professor1
  1. 1Edmond J Safra Center for Ethics, Harvard University, Cambridge, MA 02138, USA
  1. dlight{at}

The editors of the BMJ and PLOS Medicine describe the crisis of hidden or misreported information as “one of the leading scientific problems of our time.”1 As two new studies show, it has also produced an epidemic of harmful side effects from drugs with few clinical advantages to offset the harms.2 3 Patent replacement drugs are the …

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