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Letters Trial registration and publication

Don’t underestimate the extent of under-reporting

BMJ 2013; 346 doi: (Published 06 February 2013) Cite this as: BMJ 2013;346:f639
  1. Carl Heneghan, director1,
  2. Matthew Thompson, clinical reader1
  1. 1Centre for Evidence-Based Medicine, University of Oxford, Oxford OX2 6GG, UK
  1. carl.heneghan{at}

Chalmers and colleagues state that under-reporting of research “leads to overestimates of the benefits of treatments and underestimates of their harmful effects.”1

The extent of the problem should not be underestimated. A 2010 study of 546 drug trials, conducted between 2000 and 2006, reported …

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