Re: Intake of fish and marine n-3 polyunsaturated fatty acids and risk of breast cancer: meta-analysis of data from 21 independent prospective cohort studies
Dear Ju-Sheng Zheng and Professor Duo Li,
Thank you very much for your answer. But your "Conclusions - Higher consumption of dietary marine n-3 PUFA is associated with a lower risk of breast cancer" is still questionable. Women with the lowest incidental outcome of breast cancer are not those with higher consumption of dietary marine n-3 PUFA (16 178 breast cancer events and 527 392 participants).
Only those with "15 g/day increment of fish intake" consumption had the lowest incidental outcome of breast cancer (13 323 breast cancer events and 687 770 participants).
Your discussion that "dose-response analyses indicated a 5% lower risk of breast cancer per 0.1g/day or 0.1% energy/day increment of dietary marine n-3 PUFA" is also doubtful. Because it might suggest that daily intake of 2.0 gram of marine n-3 PUFA could reduce the risk of breast cancer by 100 percent?
Dr. med. Thomas G. Schätzler
Family Medicine Unit
D 44135 Dortmund/Germany
Competing interests: No competing interests