Intended for healthcare professionals

Letters Chlortalidone for hypertension

UK supply of chlortalidone for hypertension must be restored

BMJ 2013; 346 doi: (Published 15 May 2013) Cite this as: BMJ 2013;346:f3076
  1. Emma E Morrison, specialist trainee year 3, clinical pharmacology1,
  2. Emma J Turtle, McKenzie lecturer in clinical pharmacology1,
  3. David J Webb, Christison professor of therapeutics and clinical pharmacology1
  1. 1Pharmacology, Toxicology and Therapeutics, BHF Centre for Research Excellence University of Edinburgh, Queen’s Medical Research Institute, Edinburgh EH16 4TJ, UK
  1. emma.morrison{at}

In 2011 the National Institute for Health and Care Excellence (NICE) updated UK hypertension guidance.1 Bendroflumethiazide 2.5 mg, still the most commonly prescribed UK antihypertensive,2 was replaced by chlortalidone (12.5-50 mg) as the recommended thiazide-like diuretic, because of its much stronger evidence …

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