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Letters Bisphosphonates and gastrointestinal cancers

Findings of Danish study on risk of colon cancer in bisphosphonate users were misinterpreted

BMJ 2013; 346 doi: (Published 12 March 2013) Cite this as: BMJ 2013;346:f1514
  1. Bo Abrahamsen, professor1,
  2. Michael Pazianas, visiting senior fellow2,
  3. R Graham G Russell, professor2
  1. 1University of Southern Denmark, DK 5000, Odense C, Denmark
  2. 2Oxford University Institute of Musculoskeletal Sciences, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Diseases, Oxford, UK
  1. b.abrahamsen{at}

Vinogradova and colleagues misinterpreted the findings of our Danish national cohort study on the risk of colon cancer in bisphosphonate users.1 2 Moreover, they did not account for possible bias due to the longer survival of bisphosphonate users in the type of case-control studies that they performed.

Risk was reduced in long term bisphosphonate users (more than six months) in …

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