Association between maternal serum 25-hydroxyvitamin D level and pregnancy and neonatal outcomes: systematic review and meta-analysis of observational studies

So - Vitamin D should, in theory, produce a host of benefits to metabolism and outcomes in pregnancy. We also know that in these climes, levels are endemically low, and dietary Vit D is, for most, a poor source.

Furthermore, we recognise that Vitamin D supplementation in pregnancy is cheap, practical, and widely practised - and it makes giving calcium supplementation easy, (as recommended by Cochrane - see ref).

Now we are being told that meta-analysis of 31 studies (chosen from 3,357), shows clear benefits.

So how on earth do the authors reach the conclusion that what is needed is a further Randomised Controlled Trial!? What craven nonsense!

If RCTs were proof, we would not need a meta-analysis of 3000 of them to shine a light on the truth. Evidence-based medicine was never designed to be a brake on appropriate progress. Sometimes we just need plain common sense.

Ref: http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD001059.pub3/abstract