Intended for healthcare professionals

Rapid response to:


Drug-grapefruit juice interactions

BMJ 2013; 346 doi: (Published 07 January 2013) Cite this as: BMJ 2013;346:f1

Rapid Response:

Re: Drug-grapefruit juice interactions

Pirmohamed describes in depth the theoretical interactions between Statin and grapefruit juice. But he states that the interactions are difficult to quantify or predict and fails to give any absolute measure of risks. He suggests that if the Cytochrome metabolism is irreversibly poisoned by grapefruit, than statin levels might be increased a thousand-fold.

Backman, Bakhai, and McDaid have expertly shown these risks to be rare or unmeasurable in reality.

So rather than denigrate GFJ , why not turn threat into opportunity and advocate a 'polyjuice' approach - a new health drink - Grapefruit juice with a 10 microgramme dash of statin.

Can our Professor of Pharmacology, in the interest of Translational Medicine, develop a range of concentrations - and test the product in a wide range of settings - for safety and efficacy. It is obviously so cheap and acceptable it could save the NHS millions.

I waive any rights to patent or royalties.

Competing interests: No competing interests

28 January 2013
L Sam Lewis
GP Trainer
Newport Surgery
Surgery, Newport, Pembrokeshire SA42 0TJ