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Letters Coeliac disease serology

Targeting coeliac disease serology

BMJ 2012; 345 doi: (Published 10 December 2012) Cite this as: BMJ 2012;345:e8120
  1. David J Unsworth, consultant immunologist1,
  2. Francis J Smith, biomedical scientist2,
  3. Robert J Lock, consultant clinical scientist1
  1. 1Department of Immunology and Immunogenetics, Southmead Hospital, North Bristol NHS Trust, Bristol BS10 5NB, UK
  2. 2Department of Immunology, Gloucester Royal Hospital, Gloucestershire Hospitals NHS Foundation Trust, Gloucester, UK
  1. joe.unsworth{at}

We agree that testing first degree relatives of patients with coeliac disease (CD) for gluten enteropathy is worthwhile but caution against less targeted testing, especially in patients with non-specific symptoms.1

The prevalence of CD in England is estimated at 1.0-1.2%.2 3 Prevalence is higher in “at risk” groups: 5-6% in first degree relatives and 6% in people with type …

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