Short term outcomes after extreme preterm birth in England: comparison of two birth cohorts in 1995 and 2006 (the EPICure studies)BMJ 2012; 345 doi: https://doi.org/10.1136/bmj.e7976 (Published 04 December 2012) Cite this as: BMJ 2012;345:e7976
- Kate L Costeloe, professor of paediatrics12,
- Enid M Hennessy, senior lecturer (statistics)3,
- Sadia Haider, research fellow (statistics)3,
- Fiona Stacey, research nurse12,
- Neil Marlow, professor of neonatal medicine4,
- Elizabeth S Draper, professor of perinatal and paediatric epidemiology5
- 1Centre For Paediatrics, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK
- 2Homerton University Hospital NHS Foundation Trust, Homerton Row, London
- 3Wolfson Institute of Preventive Medicine, Queen Mary University of London, London
- 4Academic Neonatology, UCL Institute for Women’s Health, London
- 5Department of Health Sciences, University of Leicester, Leicester, UK
- Correspondence to: K Costeloe, Neonatal Unit, Homerton University Hospital, London E9 6SR
- Accepted 9 November 2012
Objective To determine survival and neonatal morbidity for babies born between 22 and 26 weeks’ gestation in England during 2006, and to evaluate changes in outcome since 1995 for babies born between 22 and 25 weeks’ gestation.
Design Prospective national cohort studies.
Setting Maternity and neonatal units in England.
Participants 3133 births between 22 and 26 weeks’ gestation in 2006; 666 admissions to neonatal units in 1995 and 1115 in 2006 of babies born between 22 and 25 weeks’ gestation.
Main outcome measures Survival to discharge from hospital, pregnancy and delivery outcomes, infant morbidity until discharge.
Results In 2006, survival of live born babies was 2% (n=3) for those born at 22 weeks’ gestation, 19% (n=66) at 23 weeks, 40% (n=178) at 24 weeks, 66% (n=346) at 25 weeks, and 77% (n=448) at 26 weeks (P<0.001). At discharge from hospital, 68% (n=705) of survivors had bronchopulmonary dysplasia (receiving supplemental oxygen at 36 weeks postmenstrual age), 13% (n=135) had evidence of serious abnormality on cerebral ultrasonography, and 16% (n=166) had laser treatment for retinopathy of prematurity. For babies born between 22 and 25 weeks’ gestation from March to December, the number of admissions for neonatal care increased by 44%, from 666 in 1995 to 959 in 2006. By 2006 adherence to evidence based practice associated with improved outcome had significantly increased. Survival increased from 40% to 53% (P<0.001) overall and at each week of gestation: by 9.5% (confidence interval −0.1% to 19%) at 23 weeks, 12% (4% to 20%) at 24 weeks, and 16% (9% to 23%) at 25 weeks. The proportions of babies surviving in 2006 with bronchopulmonary dysplasia, major cerebral scan abnormality, or weight and/or head circumference <−2 SD were similar to those in 1995, but the proportion treated for retinopathy of prematurity had increased from 13% to 22% (P=0.006). Predictors of mortality and morbidity were similar in both cohorts.
Conclusion Survival of babies born between 22 and 25 weeks’ gestation has increased since 1995 but the pattern of major neonatal morbidity and the proportion of survivors affected are unchanged. These observations reflect an important increase in the number of preterm survivors at risk of later health problems.
Preterm birth is associated with increased rates of neonatal mortality and long term morbidities such as respiratory problems, learning difficulties, cerebral palsy, and behavioural problems, that are highest in the most immature.1 2 This is an important public health issue as rates of preterm birth are rising in many European countries and are particularly high in the United Kingdom.3 The first EPICure study collected data for all births in the UK and Ireland before 26 completed weeks’ gestation for 10 months in 1995,4 with detailed information for those babies admitted for intensive care. Outcomes for surviving children have been reported to the age of 11.5 Since 1995 there has been emphasis on several evidence based interventions to reduce neonatal morbidity. These include increased use of antenatal corticosteroids to promote lung maturation,6 strategies to avoid neonatal hypothermia at birth,7 increased use of surfactant replacement,8 and reduction in the use of postnatal corticosteroids given to prevent bronchopulmonary dysplasia but now thought to be associated with increased cerebral palsy.9 From around 2001 neonatal services in England have been organised into clinical “networks” aiming to centralise delivery and intensive care for the most immature infants into tertiary hospitals with greater experience and 24 hour access to neonatal specialist staff.10 Regional population based data from the UK show reduced mortality for births before 26 weeks’ gestation since 1995.11 It is less clear whether there has been change in survival without major morbidity. Reduced severe developmental delay and disability were reported for cohorts from Victoria, Australia, for babies with birth weights below 1000 g in 1997 and 2005.12 In hospital based populations of babies born before 25 weeks’ gestation in the United States in 1999-2001 and 2002-04, however, there were no significant changes either in survival or in the prevalence of neurodevelopmental impairment.13
Information about the likelihood of survival and childhood impairments is important when discussing clinical decisions with parents and planning services and should be based on the best available data. We have outcomes for births before 26 weeks’ gestation in England from the EPICure study of births in 1995. To know whether these outcomes can be extrapolated to babies born in 2006 and more recently requires an understanding of whether the prediction of outcome based on early findings has changed in relation to changes in clinical practice.
EPICure 2 was designed to measure survival and morbidity after extreme preterm birth in 2006 in England and to compare outcomes with outcomes for children in the first EPICure cohort. The first EPICure study recruited births up to and including 25 completed weeks of gestation (that is, up to 25 weeks and 6 days’ gestation). In recruitment for EPICure 2 this was extended to include all births at 26 weeks gestational age (that is, 26 weeks and 0 days to 26 weeks and 6 days) both because of a lack of reliable data for babies born at 26 weeks and because babies at this gestation routinely receive active care at birth, forming a useful comparator group. We report outcomes until initial discharge from hospital for babies born in 2006 between 22 and 26 weeks’ gestation and compare outcomes for babies born between 22 and 25 weeks in 1995 and 2006.
Data collection, completeness, and quality
Births in 2006
Details of all births reported between 22 and 26 weeks’ gestation, or more immature but with birth weight over 400 g, were collected prospectively in all 182 maternity hospitals in England. All low risk midwife led centres were contacted early in 2007 to collect details of any births meeting these criteria. To avoid duplication of national data collection we carried out this data collection in collaboration with the Centre for Maternal and Child Health Enquiries. Terminations of pregnancy have been reported separately14 and, together with information on births to mothers not usually resident in England, are excluded from this analysis.
We identified contacts in the labour ward and neonatal unit of each hospital to lead the data collection. Monthly logs of eligible births were returned to the EPICure office for monitoring and validation. A member of the study team visited hospitals to collect and complete missing forms and data items. Data were double entered on a bespoke database with intervariable and intravariable range checks to facilitate the highest possible data quality. National data based on gestation at birth were not available at the time of data collection so final checks of completeness were limited to those areas where gestational age based data are routinely collected. The dataset used in 2006 was based on that used in 1995; a complete list of items in the dataset is provided in appendix 1.
Comparison between births in 1995 and 2006
In 1995 data enabling confirmation of gestational age were collected only for those babies admitted for intensive care. Our comparisons are therefore between admitted babies born between 22 and 25 weeks’ gestation from the 2006 cohort and, to standardise the geographical area, the subset of 666 admitted babies from the 1995 cohort who were born in England.
In 1995, cohort data collection was from 1 March to 31 December. Analyses for the 2006 cohort were run on the whole year and then separately for 1 March to 31 December. There were no large differences; the difference in survival was 0.7%, and the largest difference for any other outcome was 1.3% for treated retinopathy of prematurity. Data are therefore presented for the whole year for 2006 and the 10 month period in 1995.
For both cohorts we based the estimation of gestational age on accepted current best practice. In the 2006 cohort, the earliest ultrasound dating scan was used and, in the absence of any scan, the date of the last menstrual period if it was certain.15 In the absence of either scan or certain dates, we based gestation on clinical estimation. In 1995 we based gestation on date of last menstrual period unless a dating ultrasound scan performed before 20 weeks’ gestation was discrepant by over 14 days.
Recalculation of gestational age of births in 2006 with the algorithm used in 1995 resulted in a median increase in gestation of 0.2 days and a reduction of total births estimated to be between 22 and 26 weeks’ gestation from 3133 to 3088. As survival and major morbidities were within SD 0.5% of each other, we used the 2006 estimate throughout.
We measured survival for both cohorts to discharge from hospital. In 2006 survival was calculated based on babies alive at the onset of labour, babies born alive, babies admitted for intensive care, and babies who survived seven days or more. The population alive at the onset of labour was defined by the documented presence of a fetal heart rate either when labour was first diagnosed or caesarean section started or by live birth. In 1995 survival was based on admissions and those surviving seven days or more.
For babies surviving to discharge from hospital we recorded continued oxygen supplementation at 36 weeks’ postmenstrual age (bronchopulmonary dysplasia), findings on cerebral ultrasonography, treated retinopathy of prematurity, surgically treated necrotising enterocolitis, and growth (weight and head circumference) using the same definitions as in 1995.4 For 2006 births we additionally recorded details of infections with positive results on blood culture and the severity of both bronchopulmonary dysplasia (moderate disease: no mechanical support and receiving less than 30% or ≤0.1 L/minute oxygen; severe disease: mechanical support or higher oxygen concentrations, observations made at 36 weeks’ postmenstrual age)16 and retinopathy of prematurity (stages I-V).17 Findings on cerebral ultrasonography are presented for the last scan data that were available.
Survival without major morbidity was defined as survival to discharge without severe changes on cerebral ultrasonography (no ventrigulomegaly, echodense haemorrhagic parenchymal infarction, porencephaly, or periventricular leucomalacia ) on any scan, “severe” bronchopulmonary dysplasia,16 retinopathy of prematurity ≥stage 3, or laparotomy for necrotising enterocolitis.
Determinants of death and major morbidity
We developed prediction models using those items known within 24 hours of birth that had been used in the analysis of the 1995 cohort.4 These models were used to investigate any changes between 1995 and 2006 (cohort effect) in the survival of admitted babies and major morbidity (major cerebral injury on ultrasonography, bronchopulmonary dysplasia, continued use of supplementary oxygen at 40 weeks’ postmenstrual age, and treated retinopathy of prematurity).
Outcomes were summarised as proportions, means, and medians, as appropriate. We used logistic, linear, and centile regressions, respectively, to investigate the effect of gestational age (in decimal weeks). For each week of gestation, we report exact 95% binomial confidence intervals of percentages and percentage differences.
In the prediction models we used interaction terms to test whether the associations of variables with outcomes were different in the two cohorts. Any unexplained differences between 1995 and 2006 were tested using “cohort” as a variable, thus cohort is included in all the models. We used multivariable logistic regression with a manual forward stepwise procedure with replacement.
Stata statistical software (release 10.1; College Station, TX) was used for all analyses and Kaplan-Meier survival curves. No allowance was made for multiple tests, and significance was set at P≤0.05.
A total of 3378 births were reported to the study centre. Consideration of ultrasound scans and menstrual dates confirmed the gestation of 236 to be outside the range 22-26 weeks. Data for nine other births were excluded, two at parental request and seven, all of whom were either stillborn or died in the delivery room, because there was inadequate information to determine gestational age. The 3133 births in which gestation was confirmed as between 22 and 26 weeks form the basis of our analysis (table 1⇓). One baby was stillborn in a midwife led maternity unit, 34 (19 live births) were born at home, and 27 (19 live births) were born elsewhere outside the hospital.
For 3039 (97%) fetuses, gestation was confirmed by ultrasonography; the median gestation at the first dating scan was 12 weeks and 4 days (interquartile range 11 weeks 1 day-14 weeks 5 days). Of the 94 remaining, menstrual dates were certain for 16 and the gestational age for 78 was agreed by clinical assessment; in three of these the paediatricians revised the obstetric assessment. Validation of the data for the East Midlands and Yorkshire regions with data from the neonatal survey18 indicated a match for over 98% cases before the final completion of the cohort.
Of the total of 3133 babies, the proportion known to be alive at the onset of labour (n=2326) ranged from 57% (n=272) at 22 weeks’ gestation to 81% (n=594) at 26 weeks, (P<0.001 table 1⇑). Of 1099 stillbirths, 715 were antepartum and 292 were intrapartum; the time of fetal death of the 92 other was unknown.
Status at delivery and care at birth
Of the 2326 babies known to be alive at the onset of labour, 2034 were born alive; the proportion ranged from 56% (n=152) at 22 weeks’ gestation to 98% (n=580) at 26 weeks (P<0.001; table 1⇑). The proportion of liveborn babies for whom active stabilisation was withheld at birth decreased with increasing gestation: 73% (111/152) at 22 weeks, 16% (55/338) at 23 weeks, and <2% (23/1535) at 24-26 weeks (table 1⇑). Of the 78 babies born after 23 completed weeks for whom stabilisation was withheld, six (8%) had a potentially lethal malformation known before, or apparent at, birth. Three babies were admitted to a neonatal unit for palliative care; all died within 24 hours of admission.
Of the liveborn babies offered stabilisation, 95% (1751/1838) had endotracheal intubation and 72% (1303/1810) were treated with surfactant in the delivery room. Delivery room surfactant use increased linearly with gestational age from 46% (19/41) at 22 weeks’ gestation through 66% (183/276) at 23 weeks to 77% (435/565) at 26 weeks (P<0.001). Occlusive wrapping to prevent hypothermia was applied at birth to 62% (1176/1891) of liveborn babies, increasing from 16% (24/148) at 22 weeks’ gestation through 53% (169/321) at 23 weeks to 72% (376/525) at 26 weeks (P<0.001). The frequency of hypothermia at admission reduced with increasing gestational age (table 1⇑), even after adjustment for the use of occlusive wrapping: odds ratio 0.54 per week (confidence interval 0.46 to 0.62). Full details of birth weight for liveborn babies and those admitted for neonatal intensive care by gestation, sex, and plurality are provided in appendices 2 and 3.
Survival to 28 days and to discharge from hospital rose with increasing gestational age (table 1⇑). For the lower gestational ages, because death was more common in the delivery room, there are important differences in survival to 28 days and to discharge from hospital when it is expressed using admissions rather than live births as the denominator. In 2006, babies died on average 6.7 days (confidence interval 4 to 9 days) later per additional week of gestational age (fig 1⇓). Median length of stay in hospital for all survivors was 102 days (interquartile range 86-113 days), decreasing from 124 days at 22 weeks’ gestation to 134 days at 23 weeks and 91 days at 26 weeks (P<0.001; table 1⇑).
Antenatal steroids—Of liveborn babies, 76% had been exposed to antenatal steroids, increasing from 14% at 22 weeks’ gestation to 58% at 23 weeks, 84% at 24 weeks, 88% at 25 weeks, and 86% at 26 weeks; 46% overall received a complete course. Between 24 and 26 weeks’ gestation, 55% of babies admitted to neonatal intensive care received a complete course of antenatal steroids compared with 30% at 23 weeks’ gestation; table 1⇑).
Surfactant—Of the 1281 admitted babies known to have been treated with surfactant replacement in the delivery room, 931 (72%) received at least one further dose after admission. A further 361 of the 377 babies who did not receive surfactant in the delivery room were treated after admission, so that 99% of babies admitted received some surfactant treatment.
Nutrition—All but one of the surviving babies received parenteral nutrition in the days after birth; 96% received maternal breast milk at some time and 42% continued to receive some breast milk at discharge from hospital. Rates of breast feeding did not vary significantly with gestational age.
Postnatal steroids—Steroids were used to aid the weaning of babies from ventilation in 16% (161/1039) of survivors (21% (122/593) born before 26 weeks of gestation), starting at a median age of 29 days (interquartile range 20-45) and given for a median of 12 days (8-20). No baby was started on steroids for this indication within the first seven days. Of the surviving treated babies, 150 (94%) were prescribed dexamethasone: median starting dose 0.2 mg/kg/day (interquartile range 0.15-0.5). Steroid use was more common at lower gestational ages (P<0.001); the timing of commencement, duration of use, and starting dose did not change with gestation.
Major morbidity in survivors to discharge
Respiratory morbidity—Of the 761 babies who were still alive at 36 weeks postmenstrual age and still receiving supplementary oxygen, 293 (39%) were classified as having moderate and 468 (61%) as severe bronchopulmonary dysplasia; three (1%) of the moderate group and 44 (9%) of the severe group died without leaving hospital. Of the survivors, 36% of the moderate and 62% of the severe group were discharged home with supplementary oxygen.
Findings on cerebral ultrasonography—Unlike the other major morbidities, the proportion of surviving babies who had a severe abnormality reported on cerebral ultrasonography (13%, 95% confidence interval 11% to 15%) was not related to gestational age (table 2⇓).
Treated retinopathy of prematurity—Of the 166 surviving babies who had laser treatment for retinopathy, 150 (90%) had stage 3 to stage 5 disease, and 162 (98%) had both eyes treated.
Laparotomy for necrotising enterocolitis—Laparotomies for necrotising enterocolitis were performed in 79 (8%) surviving babies. Details were not collected for episodes of necrotising enterocolitis treated medically.
Overall 423 (41%) of survivors to discharge from hospital had no reported major morbidity.
Comparison of outcomes for children born in 1995 and 2006 between 22 and 25 weeks’ gestation
Characteristics of admitted babies
Table 3⇓ gives comparative characteristics for the two cohorts. The number of admissions for neonatal care of babies born from March to December with gestational age between 22 and 25 weeks increased by 44% from 666 in 1995 to 959 in 2006. The numbers of admissions varied by ethnic group, being higher for babies born to Afro-Caribbean women and those from the Indian subcontinent, so that the proportion of babies born to white women decreased significantly (table 3).
From 1995 to 2006, the proportions of admitted babies born after exposure to tocolytics and antenatal steroid increased, as did reports of birth after a clinical diagnosis of chorioamnionitis, while the prevalence of antepartum haemorrhage decreased. In contrast, the proportion of singleton births, boys, and births by caesarean section, both before and after the onset of labour, and the distribution of birth weight by gestation were similar between the two cohorts. Improved early condition of babies born in 2006 was reflected in more having a heart rate over 100 beats per minute by five minutes, many fewer having admission temperatures below 35°C, and lower median and mean clinical risk index for babies (CRIB I) scores19 (table 3).⇑
Changes in survival
Survival to discharge from hospital for all admitted babies born between 22 and 25 weeks’ gestation increased from 40% (266/666) in 1995 to 53% (593/1115) in 2006, an increase of 13% (95% confidence interval 8% to 18%). Survival increased at each week of gestation: by 9.5% (−0.1% to 19%) at 23 weeks, 12% (4% to 20%) at 24 weeks, and 16% (9% to 23%) at 25 weeks. This improved survival reflects the greater numbers of babies surviving the first week after birth; the probability of survival for babies at each week of gestation for those who survived the first seven days was no different between the two cohorts (fig 1).⇑
The median age at death in 2006 was 7 days, compared with 2 days in 1995; this is reflected in changes in the reported principal cause of death in the babies who died: fewer deaths in 2006 were attributed to very early respiratory failure (pulmonary insufficiency) and more to later complications of prematurity: infection and necrotising enterocolitis (table 4⇓). Expressed as a proportion of those alive on the seventh day, in 2006 death from infection was 4% higher (95% confidence interval 0.5% to 7%) and death from necrotising enterocolitis was 4% (2% to 6%) higher.
The median length of stay in hospital for all survivors decreased from 119 to 111 days (−8 days, 95% confidence interval −15 to −1 day); there was no change at 23 weeks’ gestation, a decrease of 16 days at 24 weeks, and a decrease of 10 days at 25 weeks
Changes in neonatal morbidities
The prevalence of major morbidities in survivors in 2006 was strikingly similar to 1995, with no differences in the proportions with bronchopulmonary dysplasia, major cerebral injury (ventriculomegaly, haemorrhagic parenchymal infarcts, or parenchymal cysts) on the last available ultrasound scan (fig 2⇓), or of the decrease in the SD score for birth weight and occipitofrontal circumference between birth and the expected date of delivery (fig 3⇓). In contrast, the proportion of babies discharged while still receiving supplementary oxygen (41%) had increased by 7% (95% confidence interval −0.2% to 14%) and the number who had laser treatment for retinopathy of prematurity increased overall by 8% (3% to 13%; fig 2), this difference was unaffected by gestational age.
Determinants of outcomes
The univariable associations were strikingly similar between the two cohorts (see appendix 3). The most notable changes were, firstly, the weakening of the relation between hypothermia and death and, secondly, the lack of association between transfer after birth with either severe abnormality on cerebral ultrasonography or prolonged requirement for oxygen. This occurred despite an increased proportion of babies being transferred within 24 hours of birth (table 3⇑). Antepartum haemorrhage and CRIB I score showed different associations in the two cohorts (see appendix 3). In the multivariable prediction models, the perinatal variables in table 5⇓ were significantly associated with one or more adverse outcome in the combined cohorts and, with the exception of CRIB I score, similarly when we considered each cohort separately. The association between CRIB I score and death before discharge was different between the two cohorts (odds ratio 0.93, 95% confidence interval 0.97 to 0.99).
Two variables, neither of which was predictive with any outcome in the combined cohorts, had significant associations in one cohort when we considered them independently: transfer within 24 hours of birth with severe abnormality on cerebral ultrasonography in 1995 and antepartum haemorrhage with survival in 2006. CRIB I score was associated with treated retinopathy of prematurity in 2006 (odds ratio 1.10, 95% confidence interval 1.02 to 1.18) but not in 1995.
The effect of cohort (table 5⇑) describes the risk of adverse outcomes after adjustment for the condition of the baby in the first 24 hours. For each outcome considered the risk was greater in 2006 but only significantly so for treated retinopathy of prematurity, suggesting that the improvement observed in survival relates to improved early condition rather than to any later factors.
This study tracking outcomes of extremely preterm births in a large geographically defined population showed improved survival in 2006 compared with 1995 and several markers of improved clinical practice. Despite this, the pattern of major short term morbidities and the associations between early clinical items and adverse outcomes were similar.
EPICure 2 represents the first opportunity to report the changes over time for perinatal and neonatal outcomes of a whole country’s extremely preterm births. Planning support for survivors of preterm birth requires an understanding of their needs through childhood and adolescence into adult life. The survivors from the first EPICure study, who were born in 1995, form the largest reported population based cohort of extremely preterm survivors; their follow-up has documented a range of problems associated with preterm birth with lifelong implications.5 20 21 22 23 EPICure 2 provides not only more recent information but also the opportunity to study any changes in the pattern of morbidity in survivors so that we can better understand whether the longer term outcomes of the 1995 EPICure cohort are valid for babies born more recently.
We decided to limit the study to England for practical reasons in anticipation of around 3500 births and 1650 admissions; in 1995 there had been no differences in major morbidities between England and the other UK countries and Ireland. We included births at a gestational age of 26 weeks in 2006 because of lack of population based data for those babies and because such babies are routinely offered intensive care, thus providing a useful comparator group. We found no stepwise differences in outcome between 25 and 26 weeks, rather a continuum of morbidity-free survival across the gestation range.
The rates of preterm birth in the UK, while lower than in the US, seem to be higher than in other European countries.3 The significant increase in admissions before 26 weeks’ gestation between the two cohorts needs to be better understood. In the East Midlands Region of the UK, there was no increase in extremely preterm admissions over the same time period,11 suggesting that there might be geographical variation. The change in the ethnicity profile between the two cohorts is difficult to interpret and takes no account of new waves of immigration over this period, which covers the incorporation of Eastern European countries in to the European Union with associated economic migration into the UK; details of the country of birth of the mother were not collected.
Overall survival in 2006 has increased since 1995, although not significantly for births before 24 weeks’ gestation. This change results from improved survival to the end of the first week, with little difference thereafter. There is evidence of increased adherence to evidence based practice in 2006, which could account for improved condition of babies shortly after birth and explain improved outcomes in the first week. The prevalence of major morbidities in survivors, however, seems not to have improved either when evaluated alone or after adjustment for status within 24 hours of birth.
The apparent absence of improved survival in 2006 after the first week is clinically important. Increased survival in the first week could result in a population entering the second week at higher risk of complications because of the survival of babies who would previously have died. This is supported by increased reporting of sepsis confirmed by blood culture and necrotising enterocolitis as the primary cause of death in those surviving the first week. Set against this, the lack of improvement in somatic or head growth over the admission to neonatal intensive care and the high rates of nosocomial infection reported in 2006 emphasise the urgency of developing safe and effective strategies to improve early growth and prevent late infective complications if further improvement in outcome is to be achieved. In this context three aspects of care after admission are noteworthy.
Firstly, from around 2003 the historical dispersed pattern of provision of neonatal intensive care in England was reorganised into networks with designated tertiary neonatal intensive care units and improved access to dedicated postnatal transfer services.24 Despite encouragement of antenatal maternal transfer, 42% of live births at less than 26 weeks’ gestation in 2006 took place outside the tertiary centres, and the proportion of babies transferred within 24 hours of birth for intensive care had increased significantly since 1995 (table 3⇑). Perhaps because of better trained and equipped transport teams, however, babies transferred in 2006 did not show the adverse outcomes associated with transfer seen in 1995 (table 5).⇑
Secondly, in 2006 the use of postnatal steroid in survivors declined from 71% to 21% and median length of treatment declined from 21 to 12 days. In the 1995 cohort this was associated in a dose dependent manner with severe motor impairment at 30 months.25 Furthermore, it is likely that the median starting dose (0.2 mg/kg/day) is lower and the overall exposure to steroid greatly reduced.
Thirdly, the use of any maternal breast milk in survivors, associated in 1995 with improved psychomotor developmental index at 30 months,22 increased in 2006 for those born before 26 weeks from 86% to 96%. In 2006, 43% of all surviving babies were receiving breast milk at discharge.
The emerging picture would seem to favour improved outcomes and yet the pattern of major neonatal morbidities (fig 2⇑) is strikingly similar to that in 1995. The observed increase in treated retinopathy of prematurity might represent a change of practice, with improved access to retinal screening and ophthalmologists recommending treatment at earlier stages of disease. Likewise the observed increase in the number of babies being discharged while still receiving supplementary oxygen, which is associated with earlier discharge from hospital, is likely to represent improved access to community nursing support. Neither explanation can be confirmed. Some of the variation in the strength of associations apparent in the analyses is probably because of the increased size of the 2006 cohort. A small change in reporting in 2006 to distinguish antepartum haemorrhage from placental abruption could explain the differential effect in the two cohorts, and different clinical indications for treatment of retinopathy could account for the altered association with CRIB I score. The most striking outcome of these analyses, however, is the consistency between the two cohorts and the lack of evidence, after adjustment for the condition of the baby shortly after birth, of improved survival or changed proportion of survivors with either bronchopulmonary dysplasia or severe abnormality on cerebral ultrasonography.
Clinical condition around the time of preterm birth is increasingly understood to be a critical determinant of later outcome.26 27 28 The consistency of the predictive models for short term outcomes across the two EPICure cohorts suggests that early predictors of outcomes in the 1995 cohort25 will remain predictive of longer term outcomes in the 2006 cohort.
In the context of other population based studies, direct international comparisons are complicated by a lack of standardised data collection. In a review including population based reports of live births before 26 weeks’ gestation between 1995 and 2000,2 survival for the 1995 EPICure cohort seemed to be the lowest, with the highest being from the northern part of Sweden. This was attributed to a positive approach on the part of both obstetricians and neonatologists with centralisation of specialist services and high rates of caesarean section and provision of neonatal intensive care.29 Subsequently the EXPRESS study reported outcomes for 1011 births between 22 and 26 weeks’ gestation from the whole of Sweden for 2004-07, with high survival at 12 months of age (70% of live births overall, 53% born at 23 weeks, and 85% born at 26 weeks).30 We derived a definition of survival without major morbidity for the EPICure 2006 cohort (table 2⇑) that is close to that used in the EXPRESS study. Three of the babies who survived to discharge, all of whom had major morbidity, died before their first birthday. Despite such big differences in survival between the two studies, the proportions of survivors without major morbidity at one year in the EPICure 2 (41%, 95% confidence interval 38% to 44%) and EXPRESS cohorts (45%, 41% to 50%) are similar.
Strengths of this study
The main strengths of this study are the size of the cohort, representing a complete national cohort and recruited with high ascertainment, and the quality of the data. All the babies were born over a short time span, and our findings are relevant to current practice. We received high cooperation from clinical staff and are confident that ascertainment is virtually 100%. As in the first study, all outlying and ambiguous data were checked with contributors and further checked and corrected if necessary at analysis. All data were double entered to check validity, in contrast with the first study in which only 10% of data were double entered.
We constrained our definitions of variables to match those of the original study, and it was therefore possible to track changes over time in clinical outcomes for this important vulnerable population. Additionally, in 2006 enhanced data were collected for all births, including stillbirths, so that outcomes could reliably be expressed with relevant denominators including total and live births and that further analyses could be undertaken to understand determinants of condition at birth.
Limitations of the study
In 2006 it was not possible to collect these data electronically because of patchy access to suitable computer facilities in maternity and neonatal units, and yet all data items would be expected to be available in the clinical record. The data collection imposed a huge volume of additional work for clinical staff and the checking of missing and ambiguous data is time consuming and causes delay in closing of databases and analysis. Since 2006, standardised electronic data have been collected in English neonatal units, and this is now almost universal with developing systems for the centralisation of data for audit and research purposes.31 In future, electronic data captured for routine clinical purposes should be of sufficient quality to provide the basis for such studies, making them easier, less expensive, and with results more readily available.
Gestational age is the most important predictor of survival for the preterm baby and is favoured over birth weight as the principal criterion for defining preterm cohorts. Nonetheless, the determination of gestation remains imprecise. Best practice for the estimate of gestation has changed over time; consequently a different algorithm was used for each cohort. This produced only minor differences in survival and major morbidities, so for this reason and for ease of comparison with other contemporary cohorts, we have presented outcomes for the 2006 cohort with the contemporary algorithm.
Recent changes in neonatal practice
It is important to consider whether changes since 2006 might have affected our findings. We are not aware of any reliable data supporting further centralisation of delivery of babies born before 27 weeks’ gestation in England or further improvement in the condition of babies at birth. Interest continues in minimising overexpansion of the lungs at birth and exposure to unnecessarily high concentrations of oxygen.32 Randomised trials have confirmed that the early application of nasal continuous positive airway pressure (CPAP) to babies who establish breathing spontaneously33 34 and, more recently, the use of nebulised surfactant replacement35 can reduce the number of babies who require endotracheal intubation. The role of probiotics to prevent sepsis, necrotising enterocolitis, and death remains controversial.36 Few babies born between 22 and 26 weeks’ gestation are included in the published trials of any of these interventions, and longer term outcomes have not been reported. Other factors that might in time feed through to better outcomes include collaborative quality improvement initiatives,37 which through the introduction of standardised “care bundles,” have been shown to be effective in reducing catheter related sepsis in newborn infants.38 Given the lack of change in the pattern of morbidity in surviving extremely preterm babies between 1995 and 2006, a period when evidence based practice was increasing, it seems unlikely that it has changed since 2006.
Our findings support the validity of using longer term outcome data from the 1995 EPICure cohort when considering the prognosis for contemporary babies. Though the pattern of major short term morbidities and the associations of early clinical items with adverse outcomes were similar, there has been a 44% increase in the numbers of extremely immature babies being admitted to our neonatal intensive care units. Increased admissions, increased survival, and unchanged rates of major adverse outcomes suggest that the while the total number of children surviving extremely preterm birth free from impairments will rise, so will the number with long term health problems. This represents an important increase in workload for health, educational, and social services.
What is already known on this topic
Mortality and morbidity are high after extremely preterm birth
Children who survive preterm birth experience a range of problems requiring additional help from health, educational, and social services and with lifelong implications
What this study adds
Between 1995 and 2006, the number of admissions to neonatal intensive care units of babies born between 22 and 25 weeks’ gestation increased by 44%
Survival of babies born between 22 and 25 weeks’ gestation has increased, but the proportion of survivors with major neonatal morbidity is unchanged
These changes suggest that the total number of children in the community with lifelong health problems attributable to extremely preterm birth will rise
Cite this as: BMJ 2012;345:e7976
We are grateful for the cooperation of the Confidential Enquiry into Maternal and Child Health (CEMACH); for the help of Kerry Montoute, Elizabeth Rushmer, Rachel Lee, and Catherine Kelly in the EPICure 2 office at Homerton University Hospital NHS Foundation Trust; for database development by Martin Perkins and data entry by Helen Holden at the University of Leicester; and particularly for the staff of contributing hospitals listed in appendix 5. The perinatal component of the EPICure studies was sponsored by Queen Mary, University of London. NM receives part funding from the Department of Health’s NIHR Biomedical Research Centre’s funding scheme at UCLH/UCL.
Independent members of EPICure 2 perinatal committee
Zarko Alfirevic, Alan Gibson, Shona Golightly, Alison Miller, Michael Webb, Andrew Wilkinson.
Independent members of EPICure studies steering committee
Peter Brocklehurst (chairman), Jane Abbott, Andrew Bush, Richard Cooke, Noreen Maconochie, Alison Matthews, David Matthews, Richard Morton, Maggie Redshaw, David Taylor, Nigel Turner, Diane Turner, Patrick Walsh.
Contributors: KLC and NM developed the hypothesis; KLC and ESD supervised the data collection; FS collected data for both EPICure cohorts and led the validation of EPICure 2 data; KLC, EMH, and SH analysed the data. KLC wrote the first draft and coordinated the production of the manuscript and is guarantor. All authors were involved in the interpretation of the data and writing the report; all have approved the final version.
Funding: The study was funded by the Medical Research Council (G0401525). The funders had no role in study design, data collection, data analysis, data interpretation, or writing of the report.
Competing interests: All authors have completed the ICMJE uniform disclosure form at www.icmje.org/coi_disclosure.pdf (available on request from the corresponding author) and declare: no support from any organisation for the submitted work; no financial relationships with any organisations that might have an interest in the submitted work in the previous three years and no other relationships or activities that could appear to have influenced the submitted work.
Ethical approval: The study was approved by the East London Research Committee (ref No 05/Q0605/107). Further approval was obtained (PIAG 3-07(f)/2005) to collect data without explicit consent. For surviving infants we sought consent to use the data, maintain contact with the family, and to arrange for long term developmental assessment.
Data sharing: The EPICure studies are subject to a data sharing policy that may be downloaded from www.epicure.ac.uk.
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