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Letters Intensive glycaemic control

Hard end points are needed for intensive glycaemic control in patients with type 2 diabetes

BMJ 2012; 344 doi: (Published 31 January 2012) Cite this as: BMJ 2012;344:e708
  1. John S Yudkin, emeritus professor of medicine1,
  2. Kasia J Lipska, Robert Wood Johnson fellow2
  1. 1University College London, London, UK
  2. 2Yale University School of Medicine, New Haven, CT, USA
  1. j.yudkin{at}

Hemmingsen and colleagues’ meta-analysis of intensive glucose lowering showed a reduction of 12% (95% confidence interval 3% to 21%) in microvascular events comprising composite end points of varying importance.1 Photocoagulation made a large contribution, but ophthalmologists are aware of glycaemic control when deciding on interventions. In the UK Prospective Diabetes Study (UKPDS) photocoagulation and cataract extraction contributed importantly to the end point, seemingly …

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