Re: Management of an acute painful sickle cell episode in hospital: summary of NICE guidance
Management of acute painful sickle cell episode in hospital: NICE guidance is frightening!
If this NICE Guidance (July 21, page 48) [1] is a response to my frequent queries on mounting deaths of hospitalized sickle cell disease (scd) patients [2-8] it frightens me.
The National Confidential Enquiry into Patient Outcome and Death (NCEPOD) [9] found that between 1 January 2005 and 31 December 2006 “Nine out of the 19 patients with sickle cell disease who had pain on admission and who then died had been given excessive doses of opiods” [10]
Since 1991 I have asked: “Why should West Indians and West Africans who did without morphine in their countries be put on morphine pumps when they were admitted to UK hospitals?” [7 11] Haematologists would not give Diamorphine to their daughters for severe dysmenorrhoea [12] yet scd patients are prescribed it? [13].
One Consultant Physician commented “You Haematologists have created a cohort of addicts in this hospital!” [13], so how would this GUIDANCE help both Consultants look after the same scd patients? I described “a woman who had been on continuous opiate infusion” for 6 months in an NHS hospital. [13]. How could this NICE Guidance help her?
INTERNATIONAL REACTIONS
BMJ’s 11 Rapid Responses [3] to NCEPOD REPORT included one from a Ghanaian Professor whose 31 year old son [‘SC’] walked into a Manchester hospital to die within 3 days [14], and a Ghanaian mother whose 32 year old [‘SC’] daughter walked to hospital with chest pain and breathlessness died within 18 hours [15] A commonsense approach is all that is needed [4 16 17 18] whether in Ghana [19] or Jamaica under Graham Serjeant [20] who once said “In Jamaican experience morphia or its derivatives are rarely used or necessary” [21] and that “the most painful crises may be treated in a day-care centre, the patient returning home in the evening” [22] – a different approach entirely from the UK opiod protocol of Sally Davies and Lola Oni [23].
When an English Physician who would not give Diamorphine to scd patients [12].was called “racist” by one Haematologist I responded: “White physicians who, at the risk of being misunderstood by (named haematologist), voice their displeasure at what they see happening on their wards deserve commendation, not condemnation”. [12]
With our “combined experience of 80 years covering thousands of patients in sickle cell crisis” [13] Serjeant and I have no need of NICE or NIH Guidelines espoused by some haematologists [24]. One of Serjeant’s never been transfused patients, died in the USA after transfusion [7 25], highlighting international differences in patient management. Heroin (Diamorphine) “has no accepted medical use in the United States” [26] yet NICE quotes the NIH as if it supports British practice.
OVERSEAS PATIENTS AND RELATIVES
Clinical experience [27] not haematological experience is what saves patients’ lives. Stopping opiod infusions in Washington, Maine, and Geneva got patients out of bed the very next day [28]. Opiods can mask serious pathology like ectopic pregnancy, bronchopneumonia, and cerebral malaria diagnosed only after autopsy in the scd patient just returning from holiday abroad [29 30]
SICKLE CELL DISEASE AND SICKLE CELL DISEASE PATIENT
“Treating Sickle Cell Disease” is not the same as “Managing the Sickle Cell Disease Patient” [17 31]. One in 4 male scd patients from Ghana has G6PD Deficiency [32] Ciprofloxacin given for the urinary tract infection or pneumonia that precipitated crisis could do harm. What says NICE about G6PD Deficient scd patients in painful crisis?
IS TRADE THE REAL REASON FOR USING OPIODS FOR SICKLE CELL PAIN?
Professor Elisabeth Goodman found KETOROLAC as efficient as morphine for controlling pain in sickle cell crisis but without the latter’s respiratory depression [33]. “So why do British Haematologists prefer to use morphine and diamorphine?” [34]. Three UK Haematologists gave this answer: “Ketorolac has no product license in the UK for this indication” [35]. Ringelhann and I are convinced that the chest syndrome in the UK and the USA is due to the “routine use of opiates for sickle cell crises” [36], while one UK haematologist “was concerned that narcotic analgesics could contribute to development of the sickle cell chest syndrome in patients hospitalized for painful crises” [37]. If relatives sued for opiate related deaths could NICE Guidance be used as plea in Court?
BBC NEWSNIGHT REPORTS ON HEROIN ADDICTION ADD TO CONCERN
On Newsnight August 9 and 10 2012 and BBC 4 “Crossing Continents” August 10 Heroin Addiction was covered. As I watched and listened I thought to myself “And this is the drug that NICE has recommended be given as ‘bolus injection’ [1] to someone in sickle cell pain crisis?”
DESIRABLE GOALS
1. Compile a register (a) of excellent Family Practitioners who manage scd patients themselves with minimal reliance on hospitals; (b) of Consultants on whose wards patients do not die from opiods; and (c) of Community Nurses who often know more about scd patients than other health workers. One such – Marion McTair – plus an NHS Consultant Haematologist, and a GP cooperated with me to wean a scd youth “SS” from opiods and blood transfusions to go from ‘A’ Levels to PhD in Great Britain.
2. We need Haematologists to emulate Professor Maxwell Wintrobe MD whose History of Haematologists is a masterpiece [38]
3 Concentrate on Genetic Counselling [39 40], because “Unless we Africans are involved in genetic counseling and family size limitation here in the UK the genetic burden on the National Health Service will go up and up” [41]
4 NHS Hospitals must publish monthly Opiate bills on Sickle Cell Disease patients [13] because “Chest syndrome was always there to blame, if the patient died” [42].
Felix I D Konotey-Ahulu MD(Lond) DSc(UCC) FRCP(Lond) FRCP(Glasg) DTMH(L’pool) – Kwegyir Aggrey Distinguished Professor of Human Genetics, University of Cape Coast, Ghana and Consultant Physician Genetic Counsellor in Sickle Cell and Other Haemoglobinopathies, Phoenix Hospital Group, 9 Harley Street, London W1G 9AL.
1 Gillis VL, Senthinathan A, Dzingina M, Chamberlain K, Banks K, Baker MR, Longson D [Guideline Development Group]. Management of an acute painful sickle cell episode in hospital: summary of NICE guidance. BMJ 2012; 344: e4063 [doi:101136/bmj.e4063]
2 Konotey-Ahulu FID. UK drug related deaths are still rising: So where is NICE? BMJ Rapid Response to Susan Mayor on “UK drug related deaths are still rising 2 reports say”(BMJ Sept 6 2009) http://www.bmj.com/cgi/eletters/339/sep01_1/b3536#219836
4 Konotey-Ahulu FID. Dedicated sickle cell teams. BMJ Rapid Response to Graham Serjeant’s “The case for dedicated sickle cell centres”. [BMJ 2007; 334: 477 (3 March)] http://www.bmj.com/cgi/eletters/334/7591/477#162678 [20 March 2007]
5 Dyer Clare. Inquest begins into deaths after concerns about diamorphine levels. BMJ 2009; 338: b903 [7 March]
7 Konotey-Ahulu FID. Poor care for sickle cell disease patients: This wake up call is overdue BMJ Rapid Response May 28 2008 BMJ 2008; 336: 1152 to Susan Mayor "Enquiry shows poor care for patients with sickle cell disease” on National Confidential Enquiry into Patient Outcome and Death (NCEPOD) REPORT "SICKLE: A Sickle Crisis?” (2008) http://www.bmj.com/cgi/eletters/336/7654/1152a#196224 | http://www.info@ncepod.org
9 NCEPOD (National Confidential Enquiry into Patient Outcome and Death). Sickle: A Sickle Crisis? (2008) [Sebastian Lucas (Clinical Co-ordiantor), David Mason (Clinical Co-ordinator), M Mason (Chief Executive), D Weyman (Researcher), Tom Treasurer (Chaifman) info@incepod.org
10 Mason S. Enquiry shows poor care for patients with sickle cell disease. BMJ 2008; 336: 1152
11 Konotey-Ahulu FID. Morphine for painful crisis in sickle cell disease. BMJ 1991; 302: 1604 (29 June)
15 Shoetan Cecilia. I lost my Sickle Cell disease adult daughter minutes after being given Diamotrphine intravenously when she could not breathe. BMJ Rapid Response 3 June 2008 http://www.bmj.com/cgi/eletters/336/7654/1152-a#196520
16 Serjeant GR. The case for dedicated sickle cell centres. BMJ 2007; 334: 477 (3 March)
19 Konotey-Ahulu FID. The Sickle Cell Disease Patient. Natural History from a clinico-epidemiological study of the first 1550 patients of Korle Bu Hospital Sickle Cell Clinic. 1991/1992 The Macmillan Press Ltd, London and TA’D Co 1996, Watford, Hertfordshire WD17 3ZH Watford (645 pages) [Pages 469 to 517 contain 133 Illustrative Case Histories indicating that not once was Morphine or Diamorpjhine given for pain. An iv drip before a pain killer never failed to cutail severity of pain]
20 Serjeant GR. Sickle Cell Disease Oxford University Press (Second Edition) 1992. Oxford. (632 pages).
21 Serjeant GR. Sickle Cell Disease. Oxford. Oxford University Press, 1985, page 204.
22 Serjeant GR. Sickle cell disease. Lancet 1997; 350: 725-730.
23 Davies SC, Oni L. Management of patients with sickle cell disease. BMJ1997; 315: 656-660.
25 Serjeant GR. Blood transfusion in sickle cell disease: A cautionary tale Lancet 2003; 361: 1659-60.
26 Ballas S K. Sickle Cell Pain. IASP Press. Seattle, USA, page 168.
27 Ranney Helen. “There is no single clinical experience in the United States comparable to that of Dr Konotey-Ahulu” In Summary of Symposium on Sickle Cell Disease – Diagnosis, Management, Education, and Research – In Sickle Cell Disease, Editors H Abramson, JF Berles, Doris Wethers (C. Mosby Co) 1972, page 320
34 Liesner RJ, Vandenberghe EA, Davies Sally C. Analgeisics in sickle cell disease disease. Lancet 1993; 3411: 188.
35 Ringelhann B, Konotey-Ahulu FID. Hemoglobinopathies and thalassemias in Mediterranean areas and in West Africa: Historical and other perspectives 1910 to 1997 - A Century Review. Atti dell’Accademia dell Science di Ferrara ( Milan) 1998;74: 267-307
36 Liesner RJ, Vandenberghe EA. Sudden death in sickle cell disease. Journal of Royal Society of Medicine 1993; 86: 484-485.
38 Wintrobe MM. Hematology: The Blossoming of a Science – A Story of Inspiration and Effort. Lea & Febiger, Philadelphia, 1985. [Distinguished Professor Max Wintrobe pointedly included me, a physician, to draw attention to the fact that the whole patient, not just their blood, was what Haematology was all about [pages 378-380]
39 Konotey-Ahulu FID. Sickle Cell Disease: The Case for Family Planning. Accra. ASTAB Books, Ltd 1973; 32 pages.
40 Boyo AE, Cabannes R, Conley CL, Lehmann H, Luzzatto L, Milner PF, Ringelhann B, Weatherall DJ, Barrai I, Konotey-Ahulu FID, Motulsky AG. Scientific Group on Treatment of Haemoglobinopathies and Allied Disorders. (Technical Report) 1972; 509 – 83 pages.
42 Konotey-Ahulu FID. Management of patients with sickle cell disease. African Journal of Health Sciences 1998; 5: 47 [Commenting on article of Sally Davies and Lola Oni (BMJ 315: 656 -60) "what I feel is more important in the day to day management of patients with a view to keeping them out of hospital, is clinical epidemiology which includes the circumstances of crises. Two examples suffice to illustrate what I mean: ... I fear Davies and Oni’s statement that ‘The Central Middlesex management protocol uses morphine infusions’ will make morphine the accepted drug for sickle crisis management. The consequences of such an approach are dire, especially when some UK hospitals are already making diamorphine their first choice"]
43 Konotey-Ahulu FID. Sickle Cell Disease In Successive Ghanaian Generations For Three Centuries (Manya Krobo Tribe). In The Human Genome Diversity Project: Cogitations of an African Native. Politics and the Life Sciences (PLS) 1999, Vol 18: No 2, pp 317-322. [Invited Commentary on Professor David Resnik's article: “The Human Genome Diversity Project: Ethical Problems and Solutions”] PMID: 12561789 [PubMed – indexed for MEDLINE] The named patients are marked ‘R’ denoting hereditary cold season ‘Rheumatism’ on this: http://www.konotey-ahulu.com/images/generation.jpg or http://www.sicklecell.md/images/generation.jpg
Competing interests:
Competing interests: I am one of my parents’ 11 children 3 of whom had sickle cell disease so I constantly probe how sickle cell disease patients are managed or mismanaged. We have traced the hereditary ailment in my forebears generation by generation back to 1670 AD http://www.konotey-ahulu.com/images/generation.jpg
07 September 2012
FELIX ID KONOTEY-AHULU
Kwegyir Aggrey Distinguished Professor of Human Genetics University of Cape Coast, Ghana
Consultant Physician Genetic Counsellor in Sickle Cell and Other Haemoglobinopathies
9 Harley Street, Phoenix Hospital Group, London W1G 9AL, UK
Rapid Response:
Re: Management of an acute painful sickle cell episode in hospital: summary of NICE guidance
Management of acute painful sickle cell episode in hospital: NICE guidance is frightening!
If this NICE Guidance (July 21, page 48) [1] is a response to my frequent queries on mounting deaths of hospitalized sickle cell disease (scd) patients [2-8] it frightens me.
The National Confidential Enquiry into Patient Outcome and Death (NCEPOD) [9] found that between 1 January 2005 and 31 December 2006 “Nine out of the 19 patients with sickle cell disease who had pain on admission and who then died had been given excessive doses of opiods” [10]
Since 1991 I have asked: “Why should West Indians and West Africans who did without morphine in their countries be put on morphine pumps when they were admitted to UK hospitals?” [7 11] Haematologists would not give Diamorphine to their daughters for severe dysmenorrhoea [12] yet scd patients are prescribed it? [13].
One Consultant Physician commented “You Haematologists have created a cohort of addicts in this hospital!” [13], so how would this GUIDANCE help both Consultants look after the same scd patients? I described “a woman who had been on continuous opiate infusion” for 6 months in an NHS hospital. [13]. How could this NICE Guidance help her?
INTERNATIONAL REACTIONS
BMJ’s 11 Rapid Responses [3] to NCEPOD REPORT included one from a Ghanaian Professor whose 31 year old son [‘SC’] walked into a Manchester hospital to die within 3 days [14], and a Ghanaian mother whose 32 year old [‘SC’] daughter walked to hospital with chest pain and breathlessness died within 18 hours [15] A commonsense approach is all that is needed [4 16 17 18] whether in Ghana [19] or Jamaica under Graham Serjeant [20] who once said “In Jamaican experience morphia or its derivatives are rarely used or necessary” [21] and that “the most painful crises may be treated in a day-care centre, the patient returning home in the evening” [22] – a different approach entirely from the UK opiod protocol of Sally Davies and Lola Oni [23].
When an English Physician who would not give Diamorphine to scd patients [12].was called “racist” by one Haematologist I responded: “White physicians who, at the risk of being misunderstood by (named haematologist), voice their displeasure at what they see happening on their wards deserve commendation, not condemnation”. [12]
With our “combined experience of 80 years covering thousands of patients in sickle cell crisis” [13] Serjeant and I have no need of NICE or NIH Guidelines espoused by some haematologists [24]. One of Serjeant’s never been transfused patients, died in the USA after transfusion [7 25], highlighting international differences in patient management. Heroin (Diamorphine) “has no accepted medical use in the United States” [26] yet NICE quotes the NIH as if it supports British practice.
OVERSEAS PATIENTS AND RELATIVES
Clinical experience [27] not haematological experience is what saves patients’ lives. Stopping opiod infusions in Washington, Maine, and Geneva got patients out of bed the very next day [28]. Opiods can mask serious pathology like ectopic pregnancy, bronchopneumonia, and cerebral malaria diagnosed only after autopsy in the scd patient just returning from holiday abroad [29 30]
SICKLE CELL DISEASE AND SICKLE CELL DISEASE PATIENT
“Treating Sickle Cell Disease” is not the same as “Managing the Sickle Cell Disease Patient” [17 31]. One in 4 male scd patients from Ghana has G6PD Deficiency [32] Ciprofloxacin given for the urinary tract infection or pneumonia that precipitated crisis could do harm. What says NICE about G6PD Deficient scd patients in painful crisis?
IS TRADE THE REAL REASON FOR USING OPIODS FOR SICKLE CELL PAIN?
Professor Elisabeth Goodman found KETOROLAC as efficient as morphine for controlling pain in sickle cell crisis but without the latter’s respiratory depression [33]. “So why do British Haematologists prefer to use morphine and diamorphine?” [34]. Three UK Haematologists gave this answer: “Ketorolac has no product license in the UK for this indication” [35]. Ringelhann and I are convinced that the chest syndrome in the UK and the USA is due to the “routine use of opiates for sickle cell crises” [36], while one UK haematologist “was concerned that narcotic analgesics could contribute to development of the sickle cell chest syndrome in patients hospitalized for painful crises” [37]. If relatives sued for opiate related deaths could NICE Guidance be used as plea in Court?
BBC NEWSNIGHT REPORTS ON HEROIN ADDICTION ADD TO CONCERN
On Newsnight August 9 and 10 2012 and BBC 4 “Crossing Continents” August 10 Heroin Addiction was covered. As I watched and listened I thought to myself “And this is the drug that NICE has recommended be given as ‘bolus injection’ [1] to someone in sickle cell pain crisis?”
DESIRABLE GOALS
1. Compile a register (a) of excellent Family Practitioners who manage scd patients themselves with minimal reliance on hospitals; (b) of Consultants on whose wards patients do not die from opiods; and (c) of Community Nurses who often know more about scd patients than other health workers. One such – Marion McTair – plus an NHS Consultant Haematologist, and a GP cooperated with me to wean a scd youth “SS” from opiods and blood transfusions to go from ‘A’ Levels to PhD in Great Britain.
2. We need Haematologists to emulate Professor Maxwell Wintrobe MD whose History of Haematologists is a masterpiece [38]
3 Concentrate on Genetic Counselling [39 40], because “Unless we Africans are involved in genetic counseling and family size limitation here in the UK the genetic burden on the National Health Service will go up and up” [41]
4 NHS Hospitals must publish monthly Opiate bills on Sickle Cell Disease patients [13] because “Chest syndrome was always there to blame, if the patient died” [42].
Felix I D Konotey-Ahulu MD(Lond) DSc(UCC) FRCP(Lond) FRCP(Glasg) DTMH(L’pool) – Kwegyir Aggrey Distinguished Professor of Human Genetics, University of Cape Coast, Ghana and Consultant Physician Genetic Counsellor in Sickle Cell and Other Haemoglobinopathies, Phoenix Hospital Group, 9 Harley Street, London W1G 9AL.
felix@konotey-ahulu.com felix@sicklecell.md http://www.sicklecell.md
1 Gillis VL, Senthinathan A, Dzingina M, Chamberlain K, Banks K, Baker MR, Longson D [Guideline Development Group]. Management of an acute painful sickle cell episode in hospital: summary of NICE guidance. BMJ 2012; 344: e4063 [doi:101136/bmj.e4063]
2 Konotey-Ahulu FID. UK drug related deaths are still rising: So where is NICE? BMJ Rapid Response to Susan Mayor on “UK drug related deaths are still rising 2 reports say”(BMJ Sept 6 2009) http://www.bmj.com/cgi/eletters/339/sep01_1/b3536#219836
3 Konotey-Ahulu FID. Current “hit and miss” care provision for sickle cell disease patients in the UK. http://www.bmj.com/cgi/eletters/337/jul11_2/a771#199135 BMJ Rapid Response 22 July 2008 to Susan Mayor on “Group publishes standards for adult sickle cell disease to reduce number of unexplained deaths” (BMJ 2008; 337:a771) http://www.bmj.com/cgi/eletters/337/jul11_2/a771
4 Konotey-Ahulu FID. Dedicated sickle cell teams. BMJ Rapid Response to Graham Serjeant’s “The case for dedicated sickle cell centres”. [BMJ 2007; 334: 477 (3 March)] http://www.bmj.com/cgi/eletters/334/7591/477#162678 [20 March 2007]
5 Dyer Clare. Inquest begins into deaths after concerns about diamorphine levels. BMJ 2009; 338: b903 [7 March]
6 Konotey-Ahulu FID. Inquest into diamorphine deaths; Does NCEPOD sickle cell patients report warrant a similar inquest? BMJ Rapid response 7 March 2010. http://www.bmj.com/cgi/eletters/338/mar03_3/b903#210208
7 Konotey-Ahulu FID. Poor care for sickle cell disease patients: This wake up call is overdue BMJ Rapid Response May 28 2008 BMJ 2008; 336: 1152 to Susan Mayor "Enquiry shows poor care for patients with sickle cell disease” on National Confidential Enquiry into Patient Outcome and Death (NCEPOD) REPORT "SICKLE: A Sickle Crisis?” (2008)
http://www.bmj.com/cgi/eletters/336/7654/1152a#196224 | http://www.info@ncepod.org
8 Konotey-Ahulu FID. The politics (and economics) of pain relief in the West and Third World http://www.bmj.com/cgi/eletters/341/aug11_2/c3800#240684 24 Aug 2010 BMJ Rapid Response.
9 NCEPOD (National Confidential Enquiry into Patient Outcome and Death). Sickle: A Sickle Crisis? (2008) [Sebastian Lucas (Clinical Co-ordiantor), David Mason (Clinical Co-ordinator), M Mason (Chief Executive), D Weyman (Researcher), Tom Treasurer (Chaifman) info@incepod.org
10 Mason S. Enquiry shows poor care for patients with sickle cell disease. BMJ 2008; 336: 1152
11 Konotey-Ahulu FID. Morphine for painful crisis in sickle cell disease. BMJ 1991; 302: 1604 (29 June)
12 Konotey-Ahulu FID. Opiates for sickle cell crisis. Lancet 1998; 352: 651-52 (22 August)
13 Konotey-Ahulu FID. Opiates for sickle cell crisis? Lancet 1998; 351: 1438 (9 May)
14 Blankson EJ. Sickle cell disease is managed, NOT treated. BMJ Rapid Response 18 June 2008 http://www.bmj.com/cgi/eletters/336/7654/1152-a#197350
15 Shoetan Cecilia. I lost my Sickle Cell disease adult daughter minutes after being given Diamotrphine intravenously when she could not breathe. BMJ Rapid Response 3 June 2008 http://www.bmj.com/cgi/eletters/336/7654/1152-a#196520
16 Serjeant GR. The case for dedicated sickle cell centres. BMJ 2007; 334: 477 (3 March)
17 Konotey-Ahulu FID. Management of sickle cell disease versus management of the sickle cell disease patient. BMJ Rapid Response 17 September 2008. http://www.bmj.com/cgi/eletters/337/sep08_1/a1397#202088
18 Konotey-Ahulu FID. Clinicians facing conflicting recommendations: Use commonsense? http://www.bmj.com/cgi/eletters/337/nov28_2/a2530#205677
19 Konotey-Ahulu FID. The Sickle Cell Disease Patient. Natural History from a clinico-epidemiological study of the first 1550 patients of Korle Bu Hospital Sickle Cell Clinic. 1991/1992 The Macmillan Press Ltd, London and TA’D Co 1996, Watford, Hertfordshire WD17 3ZH Watford (645 pages) [Pages 469 to 517 contain 133 Illustrative Case Histories indicating that not once was Morphine or Diamorpjhine given for pain. An iv drip before a pain killer never failed to cutail severity of pain]
20 Serjeant GR. Sickle Cell Disease Oxford University Press (Second Edition) 1992. Oxford. (632 pages).
21 Serjeant GR. Sickle Cell Disease. Oxford. Oxford University Press, 1985, page 204.
22 Serjeant GR. Sickle cell disease. Lancet 1997; 350: 725-730.
23 Davies SC, Oni L. Management of patients with sickle cell disease. BMJ1997; 315: 656-660.
24 Claster Susan, Vichinsky Elliott P. Managing sickle cell disease. BMJ 2003; 327: 1151-1155. doi: 10.1136/bmj.327.7424.1151
25 Serjeant GR. Blood transfusion in sickle cell disease: A cautionary tale Lancet 2003; 361: 1659-60.
26 Ballas S K. Sickle Cell Pain. IASP Press. Seattle, USA, page 168.
27 Ranney Helen. “There is no single clinical experience in the United States comparable to that of Dr Konotey-Ahulu” In Summary of Symposium on Sickle Cell Disease – Diagnosis, Management, Education, and Research – In Sickle Cell Disease, Editors H Abramson, JF Berles, Doris Wethers (C. Mosby Co) 1972, page 320
28 Konotey-Ahulu FID. Malaria and sickle cell: “Protection?” Or “No Protection?” – Confusion reigns. http://www.bmj.com/cgi/eletters/337/oct01_3/a1875#203067 BMJ Rapid Response Oct 13 2008.
29 Konotey-Ahulu FID. Imported malaria in the UK: Unde venis? & Quo vadis? BMJ Rapid Response http://www.bmj.com/cgi/eletters/337/jul03_2/a135#198874 July 16 2008
30 Konotey-Ahulu FID. Sickle cell disease and the patient. Lancet 2005; 365: 382-83
31 Konotey-Ahulu FID. G6PD Deficiency in Ghanaians: How to recognize it.
http://blog.konotey-ahulu,com/blog/_archives/2008/1/16/3458557.html Jan. 16 2008
32 Goodman Elisabeth. Use of ketorolac in sickle cell disease and vaso-occlusive crisis. Lancet 1991; 338: 641-42.
33 Konotey-Ahulu FID. Opiates for pain in dying patients and in those with sickle cell disease. http://www.bmj.com/cgi/eletters/335/7622/685#177986 11 October 2007, BMJ Rapid Response
34 Liesner RJ, Vandenberghe EA, Davies Sally C. Analgeisics in sickle cell disease disease. Lancet 1993; 3411: 188.
35 Ringelhann B, Konotey-Ahulu FID. Hemoglobinopathies and thalassemias in Mediterranean areas and in West Africa: Historical and other perspectives 1910 to 1997 - A Century Review. Atti dell’Accademia dell Science di Ferrara ( Milan) 1998;74: 267-307
36 Liesner RJ, Vandenberghe EA. Sudden death in sickle cell disease. Journal of Royal Society of Medicine 1993; 86: 484-485.
37 Wintrobe MM. Clinical Hematology. Lea & Febiger, Philadelphia, 1968, 755 pages.
38 Wintrobe MM. Hematology: The Blossoming of a Science – A Story of Inspiration and Effort. Lea & Febiger, Philadelphia, 1985. [Distinguished Professor Max Wintrobe pointedly included me, a physician, to draw attention to the fact that the whole patient, not just their blood, was what Haematology was all about [pages 378-380]
39 Konotey-Ahulu FID. Sickle Cell Disease: The Case for Family Planning. Accra. ASTAB Books, Ltd 1973; 32 pages.
40 Boyo AE, Cabannes R, Conley CL, Lehmann H, Luzzatto L, Milner PF, Ringelhann B, Weatherall DJ, Barrai I, Konotey-Ahulu FID, Motulsky AG. Scientific Group on Treatment of Haemoglobinopathies and Allied Disorders. (Technical Report) 1972; 509 – 83 pages.
41 Konotey-Ahulu FID. Need for ethnic experts to tackle genetic public health. Lancet 2007; 370: 1836 doi:10.1016/50140-6736(07)61771-1
http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(07)61771-1/fultext
42 Konotey-Ahulu FID. Management of patients with sickle cell disease. African Journal of Health Sciences 1998; 5: 47 [Commenting on article of Sally Davies and Lola Oni (BMJ 315: 656 -60) "what I feel is more important in the day to day management of patients with a view to keeping them out of hospital, is clinical epidemiology which includes the circumstances of crises. Two examples suffice to illustrate what I mean: ... I fear Davies and Oni’s statement that ‘The Central Middlesex management protocol uses morphine infusions’ will make morphine the accepted drug for sickle crisis management. The consequences of such an approach are dire, especially when some UK hospitals are already making diamorphine their first choice"]
43 Konotey-Ahulu FID. Sickle Cell Disease In Successive Ghanaian Generations For Three Centuries (Manya Krobo Tribe). In The Human Genome Diversity Project: Cogitations of an African Native. Politics and the Life Sciences (PLS) 1999, Vol 18: No 2, pp 317-322. [Invited Commentary on Professor David Resnik's article: “The Human Genome Diversity Project: Ethical Problems and Solutions”] PMID: 12561789 [PubMed – indexed for MEDLINE] The named patients are marked ‘R’ denoting hereditary cold season ‘Rheumatism’ on this: http://www.konotey-ahulu.com/images/generation.jpg or http://www.sicklecell.md/images/generation.jpg
Competing interests: Competing interests: I am one of my parents’ 11 children 3 of whom had sickle cell disease so I constantly probe how sickle cell disease patients are managed or mismanaged. We have traced the hereditary ailment in my forebears generation by generation back to 1670 AD http://www.konotey-ahulu.com/images/generation.jpg