Endgames Statistical Question

Restricted randomisation

BMJ 2012; 344 doi: https://doi.org/10.1136/bmj.e1324 (Published 29 February 2012) Cite this as: BMJ 2012;344:e1324
  1. Philip Sedgwick, senior lecturer in medical statistics
  1. 1Centre for Medical and Healthcare Education, St George’s, University of London, Tooting, London, UK
  1. p.sedgwick{at}sgul.ac.uk

Researchers evaluated the effects of an accelerated protocol incorporating early therapeutic exercises on functional rehabilitation in the first week after ankle sprain. A randomised controlled trial study design was used. The control treatment consisted of standard intervention incorporating protection, rest, ice, compression, and elevation. In total, 101 patients with acute grade 1 or grade 2 ankle sprain were recruited from an emergency department and a university based sports injury clinic. Participants were allocated to treatment using restricted randomisation, with random permuted blocks of four, in an allocation ratio of 1:1, and stratification by athletic background (athletic or non-athletic).1

The researchers reported that, when compared with standard care, the accelerated exercise protocol improved short term ankle function. …

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